Detailed assessment of heart failure identifies patients needing pacemaker treatment (CRT)

June 10, 2014, Umea University

By measuring how synchronised the heart chambers work together, it is possible to identify which patients with heart failure who benefit from pacemaker therapy, and which ones who do not. This is presented in a thesis to be defended by Gani Bajraktari on 10 June at Umeå University in Sweden.

Heart failure is not only a health problem for the patient but also an economic problem for society, since a large proportion of the patients have persistent symptoms like shortness of breath, fatigue, swollen legs, etc., despite that they receive treatment. Many patients get resynchronisation treatment, CRT, which means that an advanced pacemaker, which sends small, undetectable electrical impulses to both lower chambers of the heart, helps them to beat together in a more synchronized pattern. This improves the heart's ability to pump blood and oxygen to the body.

CRT treatment increases survival among these patients and provides in many cases a good result, but despite this, nearly 30 percent of the patients do not respond favourably. Identifying those patients has been a subject of interest for many years, but so far, research has only shown modest results.

Gani Bajraktari has studied the usefulness of measuring total isovolumic time, t- IVT, which is a measure of the short time during the heart cycle, during which the ventricle is neither filling or ejection blood.

His thesis shows that t-IVT is a significant independent factor for the patient's exercise capacity, clinical well-being and response to CRT. This result is independent of whether the patient has or not, the heart's pumping capacity, and presence of atrial fibrillation. By using t- IVT to identify patients likely to benefit from treatment with CRT, Gani Bajraktari considers that it is possible to optimise the selection of patients, protecting patients from unnecessary high-risk treatment and also reduce the cost of this treatment.

"The thesis shows that there is great value in measuring t-IVT using echocardiography in clinical practice," says Gani Bajraktari. "It's very important to measure t-IVT as it makes it possible to identify which patients with heart failure who benefit from resynchronization and which who do not benefit. Today, far too many are getting CRT without detectable benefit."

Explore further: IN-TIME shows equal benefit of home telemonitoring in ICD and CRT-D patients

More information: The dissertation is available online: umu.diva-portal.org/smash/reco … jsf?pid=diva2:718105

Related Stories

IN-TIME shows equal benefit of home telemonitoring in ICD and CRT-D patients

May 19, 2014
Home telemonitoring is equally effective in ICD and CRT-D patients, a subanalysis of the IN-TIME trial has shown. The findings were presented for the first time today at the Heart Failure Congress 2014, held 17-20 May in ...

Cardiac resynchronization improves survival in heart failure patients

March 31, 2014
Patients in mild heart failure who receive a specialized pacemaker known as cardiac resynchronization therapy with a defibrillator (CRT-D) may live longer than those implanted with a traditional implantable cardioverter defibrillator ...

FDA approves expanded indication for CRT devices

April 15, 2014
(HealthDay)—The U.S. Food and Drug Administration has approved an application from Medtronic for revised labeling for two cardiac resynchronization pacemakers (CRT-P) and eight cardiac resynchronization defibrillators (CRT-D). ...

Sexual health of men with chronic heart failure significantly improves with CRT

June 2, 2011
A new study published in the journal Clinical Cardiology reveals that in men with chronic heart failure, cardiac resynchronization therapy (CRT) improves patients' libido, erectile dysfunction, and sexual performance.

HFSA updates recommendations for use of cardiac resynchronization therapy

February 27, 2012
Based on a review of the latest evidence, the Guidelines Committee of the Heart Failure Society of America now recommends that the use of cardiac resynchronization therapy (CRT) be expanded to a larger group of patients with ...

Many breast cancer patients don't get treatment for heart problems

June 3, 2014
Only a third of older breast cancer patients saw a cardiologist within 90 days of developing heart problems, in a study presented at the American Heart Association's Quality of Care and Outcomes Research 2014 Scientific Sessions.

Recommended for you

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

Two simple tests could help to pinpoint cause of stroke

January 10, 2018
Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Heart-muscle patches made with human cells improve heart attack recovery

January 10, 2018
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery ...

Place of residence linked to heart failure risk

January 9, 2018
Location. Location. Location.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.