No sign of 'obesity paradox' in obese patients with stroke

June 2, 2014, The JAMA Network Journals

Researchers found no evidence of an "obesity paradox" (some studies have suggested overweight or obese patients have lower mortality rates than underweight or normal weight patients) in patients with stroke.

Obesity often is associated with increased health related complications and death. But some studies have suggested an obesity paradox that may cause some to question striving for a .

The authors sought to determine whether the obesity paradox in stroke was real or an artificial finding because of selection bias in studies. To overcome selection bias, authors only studied deaths caused by the index stroke using a Danish register of stroke and a registry of deaths. The study included 71,617 Danes for whom information was available on factors that included (BMI), age, stroke type and stroke severity.

Of the 71,617 , 7,878 (11 percent) died within the first month and, of these, stroke was reported as the cause of death of 5,512 patients (70 percent). Of the patients for whom BMI information was available, 9.7 percent were underweight, 39 percent were normal weight, 34.5 percent were overweight and 16.8 percent were obese. BMI was inversely related to average age of stroke onset (high BMI associated with younger age of onset).

"This study was unable to confirm the existence of an obesity paradox in stroke. … Obesity was not associated with a lower risk for death after a stroke. … The risk of with stroke for death did not differ from that of normal-weight patients with nor was there evidence of a survival advantage associated with being overweight." Christian Dehlendorff, M.S., Ph.D., of the Danish Cancer Society Research Center, Copenhagen, Denmark, and colleagues said in their JAMA Neurology paper.

Explore further: Low BMI is a risk factor for CVD in hypertensive patients with diabetes

More information: JAMA Neurol. Published online June 2, 2014. DOI: 10.1001/.jamaneurol.2014.1017

Related Stories

Low BMI is a risk factor for CVD in hypertensive patients with diabetes

September 3, 2013
Low BMI is a risk factor for CVD in hypertensive patients with diabetes, according to research presented at the ESC Congress today by Dr Takanori Nagahiro from Japan. The findings provide evidence for an obesity paradox in ...

Effect of obesity on patients with advanced non-small cell lung cancer

July 25, 2013
Obesity increases health risks for many things. Researchers wanted to know the impact of obesity on outcomes of patients with advanced non-small cell lung cancer. In the September issue of the International Association for ...

No evidence of survival advantage for type 2 diabetes patients who are overweight or obese

January 15, 2014
Being overweight or obese does not lead to improved survival among patients with type 2 diabetes. The large-scale study led by Harvard School of Public Health (HSPH) researchers refutes previous studies that have suggested ...

Increased risk of birth asphyxia in babies born to overweight and obese women

May 20, 2014
The risk of experiencing an oxygen deficit at birth (birth asphyxia) increases for babies born to women who are overweight or obese, according to a study by Swedish and US researchers published in this week's PLOS Medicine.

Considerable sudden death in hypertrophic cardiomyopathy

April 22, 2014
(HealthDay)—Patients with hypertrophic cardiomyopathy (HC) without traditional risk factors and with no or mild symptoms have a considerable rate of sudden cardiac death, according to a study published in the May 1 issue ...

Obesity may shorten colon cancer survival

April 9, 2014
(HealthDay)—Colon cancer patients who were obese before their diagnosis may have an increased risk of dying from their cancer and other causes, a new study finds.

Recommended for you

How your brain remembers what you had for dinner last night

January 17, 2018
Confirming earlier computational models, researchers at University of California San Diego and UC San Diego School of Medicine, with colleagues in Arizona and Louisiana, report that episodic memories are encoded in the hippocampus ...

Recording a thought's fleeting trip through the brain

January 17, 2018
University of California, Berkeley neuroscientists have tracked the progress of a thought through the brain, showing clearly how the prefrontal cortex at the front of the brain coordinates activity to help us act in response ...

Midbrain 'start neurons' control whether we walk or run

January 17, 2018
Locomotion comprises the most fundamental movements we perform. It is a complex sequence from initiating the first step, to stopping when we reach our goal. At the same time, locomotion is executed at different speeds to ...

A 'touching sight': How babies' brains process touch builds foundations for learning

January 16, 2018
Touch is the first of the five senses to develop, yet scientists know far less about the baby's brain response to touch than to, say, the sight of mom's face, or the sound of her voice.

Brain zaps may help curb tics of Tourette syndrome

January 16, 2018
Electric zaps can help rewire the brains of Tourette syndrome patients, effectively reducing their uncontrollable vocal and motor tics, a new study shows.

Researchers identify protein involved in cocaine addiction

January 16, 2018
Mount Sinai researchers have identified a protein produced by the immune system—granulocyte-colony stimulating factor (G-CSF)—that could be responsible for the development of cocaine addiction.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.