Weight gain following antidepressant use examined

June 4, 2014, The JAMA Network Journals

Modest differences exist between antidepressants with regard to weight gain among patients.

Previous work has suggested an association between antidepressant use and weight gain. The potential health consequences could be significant because more than 10 percent of Americans are prescribed an antidepressant at any given time. Obesity is associated with a host of medical conditions, including cardiovascular disease, type 2 diabetes and .

Electronic health records from a large New England health care system were used to collect prescribing data and recorded weights for adult patients (age 18 to 65 years) prescribed one of 11 common antidepressants.

The authors identified 22,610 adults _ 19,244 adults treated with an antidepressant for at least three months and 3,366 who received a nonpsychiatric intervention. Compared with the antidepressant citalopram, patients treated with bupropion, amitriptyline and nortriptyline had a decreased rate of weight gain.

"Taken together, our results clearly demonstrate significant differences between several individual antidepressant strategies in their propensity to contribute to weight gain. While the absolute magnitude of such differences is relatively modest, these differences may lead clinicians to prefer certain treatments according to patient preference or in individuals for whom is a particular concern." Sarah R. Blumenthal, B.S., Massachusetts General Hospital, Boston, and colleagues write in their JAMA Psychiatry paper.

Explore further: High doses of antidepressants appear to increase risk of self-harm in children young adult

More information: JAMA Psychiatry. Published online June 4, 2014. DOI: 10.1001/jamapsychiatry.2014.414

Related Stories

High doses of antidepressants appear to increase risk of self-harm in children young adult

April 28, 2014
Children and young adults who start antidepressant therapy at high doses, rather than the "modal" [average or typical] prescribed doses, appear to be at greater risk for suicidal behavior during the first 90 days of treatment.

Short-term antidepressant use, stress, high-fat diet linked to long-term weight gain

June 17, 2013
Short-term use of antidepressants, combined with stress and a high-fat diet, is associated with long-term increases in body weight, a new animal study finds. The results were presented Sunday at The Endocrine Society's 95th ...

Antidepressants and self-harm: For those under 24, initial dose matters

May 6, 2014
About a decade after the Food and Drug Administration first warned that antidepressant medications increase the risk of suicidal thoughts and behaviors in children, new research has found that kids and young adults starting ...

Good provider communication improves antidepressant adherence for diabetes patients

April 8, 2014
Adult patients with diabetes who trust their medical provider and feel included in treatment decisions are significantly more likely to take and maintain a newly prescribed antidepressant medication, according to a new study ...

Link between antidepressants and diabetes risk is real

September 24, 2013
Clinicians should be extra vigilant when prescribing antidepressants as they could pose a risk of type 2 diabetes, researchers at the University of Southampton have warned.

Intensive lifestyle changes lead to lasting improvement in T2DM

June 2, 2014
(HealthDay)—For obese/overweight adults with type 2 diabetes, an intensive lifestyle intervention (ILI) is associated with a reduced risk of incident depression and with better physical function, according to a study published ...

Recommended for you

Babies' babbling betters brains, language

January 18, 2018
Babies are adept at getting what they need - including an education. New research shows that babies organize mothers' verbal responses, which promotes more effective language instruction, and infant babbling is the key.

College branding makes beer more salient to underage students

January 18, 2018
In recent years, major beer companies have tried to capitalize on the salience of students' university affiliations, unveiling marketing campaigns and products—such as "fan cans," store displays, and billboard ads—that ...

Inherited IQ can increase in early childhood

January 18, 2018
When it comes to intelligence, environment and education matter – more than we think.

Modulating molecules: Study shows oxytocin helps the brain to modulate social signals

January 17, 2018
Between sights, sounds, smells and other senses, the brain is flooded with stimuli on a moment-to-moment basis. How can it sort through the flood of information to decide what is important and what can be relegated to the ...

Baby brains help infants figure it out before they try it out

January 17, 2018
Babies often amaze their parents when they seemingly learn new skills overnight—how to walk, for example. But their brains were probably prepping for those tasks long before their first steps occurred, according to researchers.

Reducing sessions of trauma-focused psychotherapy does not affect effectiveness

January 17, 2018
Posttraumatic Stress Disorder (PTSD) patients treated with as few as five sessions of trauma-focused psychotherapy find it equally effective as receiving 12 sessions.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.