Antibiotic prophylaxis cuts UTIs in congenital hydronephrosis

August 10, 2014
Antibiotic prophylaxis cuts UTIs in congenital hydronephrosis

(HealthDay)—Continuous antibiotic prophylaxis (CAP) reduces the risk of febrile urinary tract infection (UTI) in children with asymptomatic antenatal hydronephrosis (ANH), according to a study published online July 22 in the Journal of Pediatric Urology.

Daniel Herz, M.D., from Nationwide Children's Hospital in Columbus, Ohio, and colleagues examined from children referred for congenital ANH (2001 through 2011) with at least 24 months of follow-up. Children were characterized as those maintained on CAP (YCAP; 278 patients) and those not maintained on CAP (NCAP; 127 patients).

The researchers found that, overall, the incidence of febrile UTI during the follow-up period was 22.2 percent. The incidence of febrile UTI was significantly higher with NCAP (18.7 percent, compared to 7.9 percent in YCAP; P = 0.021). Independent risk factors for febrile UTI included ureteral dilation, high-grade vesicoureteral reflux, and ureterovesical junction obstruction. For children with ureteral dilation >11 mm not maintained on CAP, there was a 5.54-fold increased risk of febrile UTI when compared to those maintained on CAP (P = 0.001).

"Therefore CAP may have a significant role in reducing the risk of febrile UTI in with ANH with those identifiable risk factors, but otherwise seems unnecessary," the authors write.

Explore further: Continuous antibiotics not necessary for many children with common prenatal abnormality

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Continuous antibiotics not necessary for many children with common prenatal abnormality

July 24, 2014
Up to 5 percent of all prenatal ultrasounds uncover antenatal hydronephrosis, or enlarged kidneys, the most commonly detected prenatal abnormality in the United States. Many children with this abnormality are treated continually ...

Identifying kids, teens with kidney damage risk after first urinary tract infection

August 4, 2014
Children and adolescents with an abnormal kidney ultrasonography finding or with a combination of a fever of at least 102 degrees and infection with an organism other than E.coli appear to be at high risk for renal scarring ...

Malodorous urine often reported for infants with UTI

April 2, 2012
(HealthDay) -- Parental reports of malodorous urine increase the likelihood of a diagnosis of a urinary tract infection (UTI) in young children being evaluated for a suspected infection, according to a study published online ...

Differences in care for e-visits, office visits for sinusitis, UTI

January 18, 2013
(HealthDay)—For patients with sinusitis or urinary tract infection (UTI), follow-up is similar following office visits or e-visits, but antibiotics are more likely to be prescribed and preventive care is less likely with ...

IU analysis changing diagnosis and management of initial UTIs in young children

August 30, 2011
Analysis by Indiana University School of Medicine researchers of ten years of scientific studies has resulted in changes in American Academy of Pediatrics recommendations for how initial urinary tract infection in infants ...

Recommended for you

New study validates clotting risk factors in chronic kidney disease

January 17, 2018
In late 2017, researchers from Boston University School of Medicine (BUSM) discovered and published (Science Translational Medicine, (9) 417, Nov 2017) a potential treatment target to prevent chronic kidney disease (CKD) ...

Study reveals how MRSA infection compromises lymphatic function

January 17, 2018
Infections of the skin or other soft tissues with the hard-to-treat MRSA (methicillin-resistant Staphylococcus aureus) bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. ...

Fresh approach to tuberculosis vaccine offers better protection

January 17, 2018
A unique platform that resulted in a promising HIV vaccine has also led to a new, highly effective vaccine against tuberculosis that is moving toward testing in humans.

Newly-discovered TB blood signal provides early warning for at-risk patients

January 17, 2018
Tuberculosis can be detected in people with HIV infection via a unique blood signal before symptoms appear, according to a new study by researchers from the Crick, Imperial College London and the University of Cape Town.

New study offers insights on genetic indicators of COPD risk

January 16, 2018
Researchers have discovered that genetic variations in the anatomy of the lungs could serve as indicators to help identify people who have low, but stable, lung function early in life, and those who are particularly at risk ...

Previous influenza virus exposures enhance susceptibility in another influenza pandemic

January 16, 2018
While past exposure to influenza A viruses often builds immunity to similar, and sometimes different, strains of the virus, Canadian researchers are calling for more attention to exceptions to that rule.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.