Drugs for depression linked with failure of dental implants

September 12, 2014, McGill University
Results of 916 dental implants done on 490 patients

A team from McGill University has discovered that people who take the most common antidepressants (such as Celexa, Paxil, Lexapro, Prozac, and Zoloft, the Selective Serotonin Reuptake Inhibitors or SSRIs) are twice as likely to have dental implants fail as those who are not taking SSRIs.

"Because antidepressants, which are widely used around the world, are reported to increase the risk of and reduce , we were curious to see how they might affect dental implants," says Prof. Faleh Tamimi, the lead author on the study and a professor in McGill's School of Dentistry. "Even so, we were surprised to discover that the negative effect of SSRIs on dental implants was so strong, almost equal to that of smoking, a well-established hazard for oral health."

The researchers reached this conclusion by looking back over the records of dental implants done over a six-year period, between 2007 - 2013, in a clinic in Moncton, New Brunswick. Follow-ups took place with the patients between three and 67 months after the implant was done to see whether it had been successful.

"Unfortunately, because this study was based on data collected after the had been done rather than through interviews with incoming patients, it is impossible right now to determine the kind of SSRI dosage that could have this effect," says Tamimi. "But what this study tells us is both that further work needs to be done in the field and that whether they are planning to have or hip or knee prostheses, SSRI users should consult their physicians and plan carefully to ensure that the surgical treatment is successful."

Explore further: Widely used depression drug associated with dental implant failure

More information: The complete study is available online: jdr.sagepub.com/content/early/ … 022034514549378.full

Related Stories

Widely used depression drug associated with dental implant failure

September 3, 2014
The International and American Associations for Dental Research (IADR/AADR) have published a paper titled "SSRIs and the Risk of Osseointegrated Implant Failure – A Cohort Study." Selective Serotonin Reuptake Inhibitors ...

Study questions link between antidepressants, miscarriage

September 9, 2014
(HealthDay)—Some studies have found that women who use common antidepressants early in pregnancy face a raised risk of miscarriage, but new research suggests the link might be better explained by the depression, rather ...

Guidelines issued to prevent infection with dental work

May 14, 2013
(HealthDay)—Practitioners might consider discontinuing prophylactic antibiotics for patients with prosthetic implants undergoing dental procedures, and these patients should be encouraged to maintain appropriate oral hygiene, ...

Antidepressants and self-harm: For those under 24, initial dose matters

May 6, 2014
About a decade after the Food and Drug Administration first warned that antidepressant medications increase the risk of suicidal thoughts and behaviors in children, new research has found that kids and young adults starting ...

Recommended for you

Absence of a transcription factor halts tooth development in mid-stride

April 11, 2018
Amjad Javed, Ph.D., and University of Alabama at Birmingham colleagues have found a key role in tooth development for the transcription factor Specificity protein 7, or Sp7.

Toothpaste alone does not prevent dental erosion or hypersensitivity

March 14, 2018
The rising prevalence of dental erosion and dentin hypersensitivity has led to the emergence of more toothpastes that claim to treat these problems. While no such toothpaste existed 20 years ago, today, many such brands are ...

Study: Absence of key protein, TTP, rapidly turns young bones old

March 10, 2018
The absence of a protein critical to the control of inflammation may lead to rapid and severe bone loss, according to a new University at Buffalo study.

Sipping hot fruit teas can lead to tooth erosion

February 26, 2018
An investigation by scientists at King's College London into why some people suffer tooth erosion while others don't has found that it's not just what they eat and drink, but how they eat and drink, that increases their chances ...

Lack of guidance may delay a child's first trip to the dentist

February 19, 2018
Without a doctor or dentist's guidance, some parents don't follow national recommendations for early dental care for their children, a new national poll finds.

Researcher uses stem cells to attack bacteria and regenerate dental pulp

February 7, 2018
Emi Shimizu's research could someday transform a procedure dental patients dread: the root canal.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.