Drugs for depression linked with failure of dental implants

September 12, 2014, McGill University
Results of 916 dental implants done on 490 patients

A team from McGill University has discovered that people who take the most common antidepressants (such as Celexa, Paxil, Lexapro, Prozac, and Zoloft, the Selective Serotonin Reuptake Inhibitors or SSRIs) are twice as likely to have dental implants fail as those who are not taking SSRIs.

"Because antidepressants, which are widely used around the world, are reported to increase the risk of and reduce , we were curious to see how they might affect dental implants," says Prof. Faleh Tamimi, the lead author on the study and a professor in McGill's School of Dentistry. "Even so, we were surprised to discover that the negative effect of SSRIs on dental implants was so strong, almost equal to that of smoking, a well-established hazard for oral health."

The researchers reached this conclusion by looking back over the records of dental implants done over a six-year period, between 2007 - 2013, in a clinic in Moncton, New Brunswick. Follow-ups took place with the patients between three and 67 months after the implant was done to see whether it had been successful.

"Unfortunately, because this study was based on data collected after the had been done rather than through interviews with incoming patients, it is impossible right now to determine the kind of SSRI dosage that could have this effect," says Tamimi. "But what this study tells us is both that further work needs to be done in the field and that whether they are planning to have or hip or knee prostheses, SSRI users should consult their physicians and plan carefully to ensure that the surgical treatment is successful."

Explore further: Widely used depression drug associated with dental implant failure

More information: The complete study is available online: jdr.sagepub.com/content/early/ … 022034514549378.full

Related Stories

Widely used depression drug associated with dental implant failure

September 3, 2014
The International and American Associations for Dental Research (IADR/AADR) have published a paper titled "SSRIs and the Risk of Osseointegrated Implant Failure – A Cohort Study." Selective Serotonin Reuptake Inhibitors ...

Study questions link between antidepressants, miscarriage

September 9, 2014
(HealthDay)—Some studies have found that women who use common antidepressants early in pregnancy face a raised risk of miscarriage, but new research suggests the link might be better explained by the depression, rather ...

Guidelines issued to prevent infection with dental work

May 14, 2013
(HealthDay)—Practitioners might consider discontinuing prophylactic antibiotics for patients with prosthetic implants undergoing dental procedures, and these patients should be encouraged to maintain appropriate oral hygiene, ...

Antidepressants and self-harm: For those under 24, initial dose matters

May 6, 2014
About a decade after the Food and Drug Administration first warned that antidepressant medications increase the risk of suicidal thoughts and behaviors in children, new research has found that kids and young adults starting ...

Recommended for you

Oral cancer prognostic signature identified

December 5, 2018
Researchers in Brazil have identified a correlation between oral cancer progression and the abundance of certain proteins present in tumor tissue and saliva. The discovery offers a parameter for predicting progression of ...

Much-needed new antibiotic shows great promise for treating gum disease

October 23, 2018
A new antibiotic being developed at the University of Virginia School of Medicine appears ideal for battling periodontal disease, the leading cause of tooth loss in adults, according to dental researchers at Virginia Commonwealth ...

Researchers identify immune culprits linked to inflammation and bone loss in gum disease

October 17, 2018
An unhealthy population of microbes in the mouth triggers specialized immune cells that inflame and destroy tissues, leading to the type of bone loss associated with a severe form of gum disease, according to a new study ...

Periodontal disease bacteria may kick-start Alzheimer's

October 4, 2018
Long-term exposure to periodontal disease bacteria causes inflammation and degeneration of brain neurons in mice that is similar to the effects of Alzheimer's disease in humans, according to a new study from researchers at ...

Dental research shows that smoking weakens immune systems

September 26, 2018
As if lung cancer, emphysema and heart disease weren't enough, there's more bad news for cigarette smokers.

Regrowing dental tissue with stem cells from baby teeth

September 11, 2018
Sometimes kids trip and fall, and their teeth take the hit. Nearly half of children suffer some injury to a tooth during childhood. When that trauma affects an immature permanent tooth, it can hinder blood supply and root ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.