ICAAC: Moxifloxacin regimens are not noninferior for TB

ICAAC: moxifloxacin regimens are not noninferior for TB

(HealthDay)—For patients with uncomplicated, smear-positive pulmonary tuberculosis, moxifloxacin-containing regimens over four months are not noninferior to a control regimen, according to a study published online Sept. 7 in the New England Journal of Medicine to coincide with the Interscience Conference on Antimicrobial Agents and Chemotherapy, held Sept. 5 to 9 in Washington, D.C.

Stephen H. Gillespie, M.D., D.Sc., from the University of St. Andrews Medical School in the United Kingdom, and colleagues conducted a randomized phase 3 trial to test the noninferiority of two moxifloxacin-containing regimens versus a control regimen in 1,931 patients with uncomplicated, smear-positive . Patients were randomized to a control group (isoniazid, rifampin, pyrazinamide, and ethambutol for eight weeks followed by isoniazid and rifampin for 18 weeks); an isoniazid group (replacing ethambutol with moxifloxacin for 17 weeks followed by nine weeks of placebo); and an ethambutol group (replacing isoniazid with moxifloxacin for 17 weeks followed by nine weeks of placebo).

The researchers found that a favorable outcome was reported in fewer patients in the isoniazid and ethambutol groups (85 and 80 percent, respectively) than in the (92 percent) in the per-protocol analysis. Similar results were seen in the modified intention-to-treat analysis and all sensitivity analyses.

"Noninferiority for these regimens was not shown, which indicates that shortening treatment to four months was not effective in this setting," write the authors.
Bayer Healthcare provided moxifloxacin, and Sanofi donated rifampin.

Explore further

New antibiotic drug combo to speed up treatment of tuberculosis

More information: Abstract
Full Text
More Information
Journal information: New England Journal of Medicine

Copyright © 2014 HealthDay. All rights reserved.

Citation: ICAAC: Moxifloxacin regimens are not noninferior for TB (2014, September 8) retrieved 28 March 2020 from https://medicalxpress.com/news/2014-09-icaac-moxifloxacin-regimens-noninferior-tb.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments