Study examines immunosuppressant effect on central nervous system disorder

In patients with neuromyelitis optica spectrum disorder (NMOSD, an autoimmune inflammatory disease of the central nervous system similar to multiple sclerosis but even more debilitating), the immunosuppressant medication mycophenolate mofetil (MMF) appears to reduce the frequency of relapse, stabilize or improve disabilities and be well tolerated by patients.

Disabilities from NMOSD arise due to acute attacks and just one or two attacks can lead to blindness or a walking disability. Preventing the attacks is key to preventing the resulting disabilities. Immunosuppressants such as MMF have been used as therapies to prevent relapse in with NMOSD. The authors sought to examine the safety and efficacy of MMF treatment.

The authors conducted a three-center review that examined their experiences with 59 patients with NMOSD (24 with neuromyelitis optica and 35 with a limited form of the disease) who were treated with MMF. One of the patients discontinued use of MMF because of a rash so 58 patients were included in the drug-efficacy analysis.

The median post-MMF relapse rate was lower than the pre-MMF relapse rate (0.0 vs. 1.5) and disability scores also decreased after MMF treatment (3.0 vs. 2.5). Of the patients, 35 (60 percent) were free of and disability scores stabilized or improved in 53 patients (91 percent). MMF was generally well tolerated.

"The next step will be to conduct a with long-term efficacy and safety analyses in a larger cohort that can elucidate the efficacy of MMF treatment in patients with NMOSD." So-Young Huh, M.D., of the University College of Medicine, Busan, Korea, and colleagues said in their JAMA Neurology article.

In a related editorial, Bruce Cree, M.D., Ph.D, M.A.S., of the University of California, San Francisco, writes: "In this issue, Huh and colleagues report their experience treating 58 patients with NMO [neuromyelitis optica] using MMF. To my knowledge, this is the largest study of MMF treatment in patients with NMO reported thus far."

"Despite the apparent reductions in and improvement in disability outcomes, this study has several important limitations that must be recognized before concluding that MMF is an effective treatment for NMO. Most important, there was no parallel control arm," Cree continues.

"Are we ready to conduct clinical trials with MMF or other immune suppressants in treating NMO? Given that various treatments are used empirically to treat NMO, and patients need to know whether these empirical therapies are, in fact, effective," Cree notes.


Explore further

Genes reveal which patients will benefit from scleroderma drug

More information: JAMA Neurol. Published online September 8, 2014. DOI: 10.1001/.jamaneurol.2014.2057
JAMA Neurol. Published online September 8, 2014. DOI: 10.1001/.jamaneurol.2014.2359
Journal information: Archives of Neurology

Citation: Study examines immunosuppressant effect on central nervous system disorder (2014, September 8) retrieved 21 September 2020 from https://medicalxpress.com/news/2014-09-immunosuppressant-effect-central-nervous-disorder.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments