Ebola vaccine trials to start in Switzerland this week (Update)

Ebola vaccine trials are set to start in Switzerland this week after receiving the green light from the country's authorities, the World Health Organization (WHO) said Tuesday.

Swiss regulators announced they would allow trials of an experimental vaccine made by Britain's GlaxoSmithKine, and tests on some 120 individuals were set to get under way at the CHUV hospital in Lausanne Friday, the hospital said.

"We have never before received so many volunteers so quickly," Blaise Genton, who heads CHUV's infectuous disease division, told reporters.

He said the volunteers, who must be between the ages of 18 and 65, were mainly medical students and would all receive 800 Swiss francs ($845, 665 euros) for their participation.

Genton stressed they would receive payment for their time, since they would be spending "numerous hours with us".

Most of the volunteers will receive the experimental GSK vaccine called ChAd3, which is based on a genetically modified chimpanzee adenovirus, but 20 of them would receive a placebo he said.

WHO hailed the announcement.

"This marks the latest step towards bringing safe and effective Ebola vaccines for testing and implementation as quickly as possible," the UN's health agency said in a statement.

There is no licensed treatment or vaccine for the deadly Ebola virus, which has killed nearly 5,000 people in the outbreak centred in west Africa.

The experimental GSK vaccine is one of two considered particularly promising by WHO, and trials have already begun in Mali, Britain and the United States.

"The trial will test the safety of the vaccine and its capacity to induce an immune response," WHO said.

It added that results of the trials in Switzerland and elsewhere will "provide the basis for planning subsequent trials involving several thousand participants, and for choosing vaccine dose-level for efficacy trials."

A second experimental vaccine being fast-tracked on the WHO's recommendation, Canadian-discovered rVSV, is set to soon start trials at the University Hospital of Geneva.

Trials of that potential vaccine have already begun in the United States and are also set to soon start in Germany, Gabon and Kenya.

"If shown to be safe and effective, either of the vaccines could be scaled up for production during the first quarter of next year, with millions of doses produced for wide distribution in high-risk countries," WHO assistant director general Marie-Paule Kieny said in the statement.

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© 2014 AFP

Citation: Ebola vaccine trials to start in Switzerland this week (Update) (2014, October 28) retrieved 17 August 2022 from https://medicalxpress.com/news/2014-10-ebola-vaccine-trials-switzerland-week.html
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