Study finds association between coronary artery plaque and liver disease

Researchers using coronary computed tomography angiography (CCTA) have found a close association between high-risk coronary artery plaque and a common liver disease. The study, published online in the journal Radiology, found that a single CT exam can detect both conditions.

Previous research has shown that CCTA can detect high-risk coronary artery , or plaque prone to life-threatening ruptures. For the new study, researchers looked at associations between high-risk plaque and non-alcoholic (NAFLD), a condition characterized by abnormal liver function that is not associated with excessive alcohol consumption. NAFLD is the most common , with an estimated prevalence of 20 percent to 30 percent in the general population.

"As it is known that is linked to inflammation, our next step was to look for an association of high-risk plaques with other systemic inflammatory conditions such as NAFLD," said the study's lead author, Stefan B. Puchner, M.D., from Massachusetts General Hospital and Harvard Medical School in Boston and the Medical University of Vienna, Austria. "Interestingly, both pathologies can be detected in a single CT examination."

The researchers drew patients from a large trial focusing on the use of CCTA in people who had come to the emergency department with acute chest pain. The patients underwent both non-enhanced CT to assess coronary calcium, a marker of atherosclerosis, and contrast-enhanced CCTA. Readers assessed the CCTA images for signs of high-risk plaque.

Overall, 182 of the 445 patients in the study, or 40.9 percent, had CT evidence of NAFLD. High-risk plaque was seen in 59.3 percent of patients with NAFLD, compared to only 19 percent of those without NAFLD. The association between NAFLD and high-risk plaque persisted after adjusting for the extent and severity of coronary atherosclerosis and traditional risk factors.

The results suggest that high-risk plaque and NAFLD are both part of the same systemic disease process, the metabolic syndrome.

"The clinical implications could include a wider assessment of NAFLD using the non-contrast cardiac CT scans that are commonly performed prior to the CTA," he said. "Further, the additional assessment of NAFLD with CT could improve the risk stratification of patients with suspected , as our results show that the presence of NAFLD is associated with high-risk coronary plaque independent of traditional risk factors and severity of disease."

The researchers plan to extend the study outside of the emergency department setting to see if the results apply to other categories of the general population. They also hope to learn more about why NAFLD is so prevalent among people with advanced high-risk . One prevailing theory is that both conditions are a consequence of systemic inflammation, an inflammatory state that affects multiple organs and can lead to life-threatening conditions.

"The aim will be to further investigate and understand, with the help of CCTA, the interplay between advanced atherosclerosis and NAFLD as part of a complex systemic inflammatory condition," Dr. Puchner said.


Explore further

Dysfunctional ketogenesis promotes fatty liver disease in mice

More information: "High-Risk Coronary Plaque at Coronary CT Angiography Is Associated with Nonalcoholic Fatty Liver Disease, Independent of Coronary Plaque and Stenosis Burden." Radiology, 2014.
Journal information: Radiology

Citation: Study finds association between coronary artery plaque and liver disease (2014, November 4) retrieved 23 July 2019 from https://medicalxpress.com/news/2014-11-association-coronary-artery-plaque-liver.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more