Triple drug combo benefits lupus nephritis
Liu's team randomly assigned patients with lupus nephritis to one of two groups: One received monthly infusions of cyclophosphamide, plus oral steroid medication; the other received oral steroids, along with two immune-suppressing medications—mycophenolate mofetil and tacrolimus.
After six months, 45.9 percent of patients on the drug trio were in complete remission, and 83.5 percent had at least a partial response. In contrast, 25.6 percent of patients on cyclophosphamide were in complete remission. And 63.0 percent had at least a partial response.
"Multitarget therapy provides superior efficacy compared with intravenous cyclophosphamide as induction therapy for lupus nephritis," the authors write.
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