All vaginal estrogens effective for genitourinary sx of menopause

All vaginal estrogens effective for genitourinary sx of menopause

(HealthDay)—All vaginal estrogens are effective for women with genitourinary syndrome of menopause, according to a review published online Nov. 5 in Obstetrics & Gynecology.

David D. Rahn, M.D., from the University of Texas Southwestern Medical Center in Dallas, and colleagues conducted a systematic review to provide clinical practice guidelines relating to vaginal estrogen and its alternatives for with genitourinary syndrome of . Data were reviewed from 44 eligible studies.

The researchers found that, compared to placebo, vaginal estrogen preparations improved dryness, dyspareunia, urinary urgency and frequency, and stress and urge urinary incontinence. Similar efficacy and safety was seen for the various estrogen preparations; for all except high-dose conjugated equine estrogen cream serum, estradiol levels remained within postmenopausal norms. Among those receiving vaginal estrogen, endometrial hyperplasia and adenocarcinoma were extremely rare. Patients with two or more symptoms of vulvovaginal atrophy were considerably more improved using vaginal estrogens than nonhormonal moisturizers, whereas similar symptom resolution was seen with vaginal estrogen and nonhormonal moisturizers for those with one or minor complaints.

"In conclusion, this systematic of randomized trials and prospective comparative studies of vaginal estrogen and common alternative therapies confirms the efficacy of all commercially available vaginal estrogens for the management of genitourinary syndrome of menopause," the authors write.


Explore further

New term will banish stigma, educate providers on postmenopausal problems

More information: Full Text (subscription or payment may be required)
Journal information: Obstetrics & Gynecology

Copyright © 2014 HealthDay. All rights reserved.

Citation: All vaginal estrogens effective for genitourinary sx of menopause (2014, November 12) retrieved 24 August 2019 from https://medicalxpress.com/news/2014-11-vaginal-estrogens-effective-genitourinary-sx.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more