First comprehensive characterization of genetic diversity in Sub-Saharan Africa published

December 3, 2014, Wellcome Trust Sanger Institute
From left to right, the structures of A-, B- and Z-DNA. Credit: Wikipedia

Researchers from the African Genome Variation Project (AGVP) have published the first attempt to comprehensively characterise genetic diversity across Sub-Saharan Africa. The study of the world's most genetically diverse region will provide an invaluable resource for medical researchers and provides insights into population movements over thousands of years of African history. These findings appear in the journal Nature.

"Although many studies have focused on studying for disease in European populations, this is an understudied area in Africa," says Dr Deepti Gurdasani, lead author on the study and a Postdoctoral Fellow at the Wellcome Trust Sanger Institute. "Infectious and non-infectious diseases are highly prevalent in Africa and the for these diseases may be very different from those in European populations."

"Given the evolutionary history of many African populations, we expect them to be genetically more diverse than Europeans and other populations. However we know little about the nature and extent of this diversity and we need to understand this to identify factors for disease."

Dr Manjinder Sandhu and colleagues collected genetic data from more than 1800 people - including 320 whole genome sequences from seven populations - to create a detailed characterisation of 18 ethnolinguistic groups in Sub-Saharan Africa. Genetic samples were collected through partnerships with doctors and researchers in Ethiopia, the Gambia, Ghana, Kenya, Nigeria, South Africa and Uganda.

The AGVP investigators, who are funded by the Wellcome Trust, the Bill and Melinda Gates Foundation and the UK Medical Research Council, found 30 million genetic variants in the seven sequenced populations, a fourth of which have not previously been identified in any population group. The authors show that in spite of this genetic diversity, it is possible to design new methods and tools to help understand this genetic variation and identify genetic risk factors for disease in Africa.

"The primary aim of the AGVP is to facilitate medical in Africa. We envisage that data from this project will provide a global resource for researchers, as well as facilitate genetic work in Africa, including those participating in the recently established pan-African Human Heredity and Health in Africa (H3Africa) genomic initiative," says Dr Charles Rotimi, senior author from the Centre for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, USA.

The authors also found evidence of extensive European or Middle Eastern genetic ancestry among several populations across Africa. These date back to 9,000 years ago in West Africa, supporting the hypothesis that Europeans may have migrated back to Africa during this period. Several of the populations studied are descended from the Bantu, a of agriculturists and pastoralists thought to have expanded across large parts of Africa around 5,000 years ago.

The authors found that several hunter-gatherer lines joined the Bantu populations at different points in time in different parts of the continent. This provides important insights into hunter-gatherer populations that may have existed in Africa prior to the Bantu expansion. It also means that future genetic research may require a better understanding of this hunter-gatherer ancestry.

"The AGVP has provided interesting clues about ancient populations in Africa that pre-dated the Bantu expansion," says Dr Manjinder Sandhu, lead senior author from the Wellcome Trust Sanger Institute, UK and the Department of Medicine, University of Cambridge. "To better understand the genetic landscape of ancient Africa we will need to study modern genetic sequences from previously under-studied African populations, along with ancient DNA from archaeological sources."

The study also provides interesting clues about possible genetic loci associated with increased susceptibility to high blood pressure and various infectious diseases, including malaria, Lassa fever and trypanosomiasis, all highly prevalent in some regions of Africa. These genetic variants seem to occur with different frequencies in disease endemic and non-endemic regions, suggesting that this may have occurred in response to the different environments these populations have been exposed to over time.

"The AGVP has substantially expanded on our understanding of African genome variation. It provides the first practical framework for genetic research in Africa and will be an invaluable resource for researchers across the world. In collaboration with research groups across Africa, we hope to extend this resource with large-scale sequencing studies in more of these diverse populations," says Dr Sandhu.

Explore further: East and West African sickle cell anaemia are genetically similar

More information: Nature, dx.doi.org/10.1038/nature13997

Related Stories

East and West African sickle cell anaemia are genetically similar

November 6, 2014
Sickle cell anaemia is most common in Africa and up to 11,000 children are born with the condition every year in Tanzania alone. Yet most of what is known about the genetic basis of this inherited disease comes from studies ...

New analysis of human genetic history reveals female dominance

September 23, 2014
Female populations have been larger than male populations throughout human history, according to research published today in the open access journal Investigative Genetics. The research used a new technique to obtain higher ...

Genomics and African queens: Diversity within Ethiopian genomes reveals imprints of historical events

June 21, 2012
Researchers have started to unveil the genetic heritage of Ethiopian populations, who are among the most diverse in the world, and lie at the gateway from Africa. They found that the genomes of some Ethiopian populations ...

Study finds genetic mutations linked with ethnic disparities in cancer

September 9, 2014
One of the goals of genome sequencing is to identify genetic mutations associated with increased susceptibility to disease. Yet by and large these discoveries have been made in people of European or Asian ancestry, resulting ...

Recommended for you

Scientists identify critical cancer immunity genes using new genetic barcoding technology

October 20, 2018
Scientists at Mount Sinai have developed a novel technology for simultaneously analyzing the functions of hundreds of genes with resolution reaching the single cell level. The technology relies on a barcoding approach using ...

A single missing gene leads to miscarriage

October 19, 2018
A single gene from the mother plays such a crucial role in the development of the placenta that its dysfunction leads to miscarriages. Researchers from the Medical Faculty of Ruhr-Universität Bochum (RUB) have observed this ...

Making gene therapy delivery safer and more efficient

October 18, 2018
Viral vectors used to deliver gene therapies undergo spontaneous changes during manufacturing which affects their structure and function, found researchers from the Perelman School of Medicine at the University of Pennsylvania ...

Student develops microfluidics device to help scientists identify early genetic markers of cancer

October 16, 2018
As anyone who has played "Where's Waldo" knows, searching for a single item in a landscape filled with a mélange of characters and objects can be a challenge. Chrissy O'Keefe, a Ph.D. student in the Department of Biomedical ...

Researchers use brain cells in a dish to study genetic origins of schizophrenia

October 16, 2018
A study in Biological Psychiatry has established a new analytical method for investigating the complex genetic origins of mental illnesses using brain cells that are grown in a dish from human embryonic stem cells. Researchers ...

Why heart contractions are weaker in those with hypertrophic cardiomyopathy

October 16, 2018
When a young athlete suddenly dies of a heart attack, chances are high that they suffer from familial hypertrophic cardiomyopathy (HCM). Itis the most common genetic heart disease in the US and affects an estimated 1 in 500 ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.