Beyond prevention: Sulforaphane may find possible use for cancer therapy

January 12, 2015
Research in the Linus Pauling Institute has found that sulforaphane, found in foods such as broccoli, may be able to play a role in cancer therapy. Credit: US Department of Agriculture

New research has identified one of the key cancer-fighting mechanisms for sulforaphane, and suggests that this much-studied phytochemical may be able to move beyond cancer prevention and toward therapeutic use for advanced prostate cancer.

Scientists said that pharmacologic doses in the form of supplements would be needed for actual therapies, beyond the amount of that would ordinarily be obtained from dietary sources such as broccoli. Research also needs to verify the safety of this compound when used at such high levels.

But a growing understanding of how sulforaphane functions and is able to selectively kill cells indicate it may have value in treating metasticized cancer, and could work alongside existing approaches.

The new findings on the unique abilities of sulforaphane were recently published in the journal Oncogenesis, by researchers from Oregon State University and the Texas A&M Health Science Center. The work was supported by the National Institutes of Health.

"There's significant evidence of the value of cruciferous vegetables in ," said Emily Ho, professor and director of the Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health in the OSU College of Public Health and Human Sciences, and lead author on this research.

"However, this study is one of the first times we've shown how sulforaphane can affect a histone methylation and alter gene expression in metasticized prostate cancer cells," said Ho, who is also a principal investigator in OSU's Linus Pauling Institute. "It begins a process that can help to re-express tumor suppressors, leading to the selective death of cancer cells and slowing disease progression."

The evidence now shows that sulforaphane should have therapeutic value against some forms of cancer, Ho said, including late-stage, metasticized disease. Its multiple impacts on metabolic processes might also make it a valuable adjunct to existing therapies, helping them to work better.

No clinical trials have yet been done to test the value of sulforaphane in cancer therapy, although a trial is under way using sulforaphane supplements in men with high risk for prostate cancer. Results from that may help demonstrate the safety of higher-dosage supplements and set the stage for therapeutic trials, Ho said.

Dozens of studies have examined the health value of cruciferous vegetables such as broccoli, cauliflower, and cabbages, and many of them ultimately focused on the role of sulforaphane, one compound found in these foods. Broccoli sprouts contain some of the highest dietary levels of the sulforaphane precursor.

The new study identified a particular enzyme in prostate , SUV39H1, that is affected by exposure to sulforaphane. Aside from potential dietary approaches, the researchers said that this establishes SUV39H1 as a new therapeutic target, in general, for advanced cancer.

Prostate cancer is one of the most commonly diagnosed cancers in the United States, and existing therapies include surgical removal of the prostate, radiation therapy, hormones or other approaches. Although often slow growing, prostate cancer can be much more aggressive if it metasticizes to other areas of the body, at which point survival rates decrease dramatically. In the U.S. it's the fifth leading cause of cancer death.

In laboratory studies, sulforaphane has shown toxicity to a number of human cancer cell lines, including prostate, breast, ovarian, colon and pancreatic cancer, and in animal studies it decreased metastases of .

Explore further: Study confirms safety, cancer-targeting ability of nutrient in broccoli, other vegetables

Related Stories

Study confirms safety, cancer-targeting ability of nutrient in broccoli, other vegetables

June 9, 2011
Sulforaphane, one of the primary phytochemicals in broccoli and other cruciferous vegetables that helps them prevent cancer, has been shown for the first time to selectively target and kill cancer cells while leaving normal ...

Unusual combination therapy shows promise for preventing prostate cancer, researchers find

September 17, 2013
Combining a compound from broccoli with an antimalarial drug prevents prostate cancer in mice, University of Pittsburgh Cancer Institute (UPCI) researchers discovered.

Another mechanism discovered by which sulforaphane prevents cancer

February 28, 2012
Researchers in the Linus Pauling Institute at Oregon State University have discovered yet another reason why the "sulforaphane" compound in broccoli and other cruciferous vegetables is so good for you – it provides not ...

Steaming broccoli preserves potential power to fight cancer, study finds

November 8, 2013
(HealthDay)—The way you prepare broccoli and related vegetables can alter their potentially cancer-fighting powers, new research shows.

Vegetable compound could become ingredient to treating leukemia

December 12, 2012
It looks like your mother was on to something when she said, "Eat your vegetables!" A concentrated form of a compound called sulforaphane found in broccoli and other cruciferous vegetables has been shown to reduce the number ...

Recommended for you

Alternative splicing, an important mechanism for cancer

September 22, 2017
Cancer, which is one of the leading causes of death worldwide, arises from the disruption of essential mechanisms of the normal cell life cycle, such as replication control, DNA repair and cell death. Thanks to the advances ...

'Labyrinth' chip could help monitor aggressive cancer stem cells

September 21, 2017
Inspired by the Labyrinth of Greek mythology, a new chip etched with fluid channels sends blood samples through a hydrodynamic maze to separate out rare circulating cancer cells into a relatively clean stream for analysis. ...

Drug combination may improve impact of immunotherapy in head and neck cancer

September 21, 2017
Checkpoint inhibitor-based immunotherapy has been shown to be very effective in recurrent and metastatic head and neck cancer but only in a minority of patients. University of California San Diego School of Medicine researchers ...

Whole food diet may help prevent colon cancer, other chronic conditions

September 21, 2017
A diet that includes plenty of colorful vegetables and fruits may contain compounds that can stop colon cancer and inflammatory bowel diseases in pigs, according to an international team of researchers. Understanding how ...

New kinase detection method helps identify targets for developing cancer drugs

September 21, 2017
Purdue University researchers have developed a high-throughput method for matching kinases to the proteins they phosphorylate, speeding the ability to identify multiple potential cancer drug targets.

Poliovirus therapy induces immune responses against cancer

September 20, 2017
An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body's own capacity to fight malignancies by activating an inflammation process that counter's the ability of cancer cells ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.