HPV-16 tied to improved survival in advanced esophageal cancer

HPV-16 tied to improved survival in advanced esophageal cancer

(HealthDay)—For patients with advanced-stage esophageal squamous cell carcinoma (ESCC), human papillomavirus (HPV)-16 infection is associated with improved survival and treatment response, according to a study published online Feb. 24 in the Journal of Digestive Diseases.

Wen-Lun Wang, M.D., from the E-Da Hospital/I-Shou University in Taiwan, China, and colleagues examined the impact of HPV infection on the prognosis and of ESCC in a cohort of 150 patients. The presence and subtype of HPV-DNA in tumor specimens was assessed by and sequencing.

Eighteen percent of ESCC tumor samples were HPV-positive, of which 81.5 percent were positive for HPV-16 infection. The researchers observed no difference between HPV-positive and HPV-negative groups in terms of the prevalence of developing multiple ESCC (29.6 and 28.5 percent, respectively; P = 0.90). Survival was significantly better for patients with HPV-16 positive advanced-stage ESCC compared with HPV-negative disease (three-year survival, 55 versus 21 percent; log-rank P = 0.03), in subgroup analysis. The presence of HPV-16 correlated with a significant decrease in the mortality rate (hazard ratio, 0.41). Chemoradiation response was better for patients with versus those without HPV-16 infection (P = 0.026).

"In patients with advanced stage ESCC, HPV-16 positive patients had a significantly favorable survival, especially for those who receiving chemoradiation therapy," the authors write.

Explore further

High prevalence of anal HPV in men who have sex with men

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2015 HealthDay. All rights reserved.

Citation: HPV-16 tied to improved survival in advanced esophageal cancer (2015, March 4) retrieved 16 January 2021 from https://medicalxpress.com/news/2015-03-hpv-tied-survival-advanced-esophageal.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments