Concomitant metformin, GERD meds up vitamin B12 depletion

April 23, 2015

Concomitant metformin, GERD meds up vitamin B<sub>12</sub> depletion
(HealthDay)—Concomitant use of metformin and histamine H2-receptor antagonists or proton pump inhibitors has the potential to induce vitamin B12 depletion and neuropathy, according to research published in the April issue of Clinical Diabetes.

Matthew J. Zdilla, from West Liberty University in West Virginia, examined the potential for vitamin B12 depletion induced by concomitant use of and acid-suppressing medications, as well as their contribution to among patients with diabetes.

Zdilla notes that among individuals with diabetes, 40.7 percent have and 70 percent of those take oral antidiabetic agents. Individuals treated with metformin have lower B12 levels and worse diabetic neuropathy than those managed with other medications. Metformin-induced B12 depletion is likely due to a decrease in bile acid secretion, decreased intrinsic factor secretion, and decreased intestinal absorption. Histamine H2-receptor antagonists and interfere with B12 absorption and result in B12 depletion, with reports attributing depletion to decreased gastric acid, pepsin, and intrinsic factor output. Concomitant therapy is likely to have an additive effect on B12 levels and the potential for neuropathy.

"Pharmacists, clinicians, and patients need to be aware of the potential for polypharmacy-induced B12 depletion and the potential for subsequent neuropathy," Zdilla writes. "Awareness is particularly important because metformin and acid-suppressing medications are commonly used in the diabetic population, which has a high prevalence of neuropathy."

Explore further: Acid-suppressing medications associated with vitamin B12 deficiency

More information: Abstract
Full Text

Related Stories

Acid-suppressing medications associated with vitamin B12 deficiency

December 10, 2013
Use for 2 or more years of proton pump inhibitors and histamine 2 receptor antagonists (two types of acid-inhibiting medications) was associated with a subsequent new diagnosis of vitamin B12 deficiency, according to a study ...

Plasma B12 levels tied to anorexia nervosa severity

April 1, 2015
(HealthDay)—In patients with anorexia nervosa, plasma levels of vitamin B12 might be an early marker of liver dysfunction and are possibly related to more severe psychopathological aspects, according to a study published ...

Metformin may increase risk of cognitive impairment

September 21, 2013
(HealthDay)—Metformin may increase the risk of cognitive impairment in patients with diabetes; however, calcium supplementation may attenuate this risk, according to research published online Sept. 5 in Diabetes Care.

Low vitamin B12 linked to postural orthostatic tachycardia

December 23, 2013
(HealthDay)—During adolescence, low vitamin B12 levels are associated with postural orthostatic tachycardia syndrome (POTS), according to a study published online Dec. 23 in Pediatrics.

Median neuropathy at the wrist may signal diabetic neuropathy

November 3, 2014
(HealthDay)—Median neuropathy at the wrist (MN) may be an early indicator of diabetic neuropathy, according to a study published in the November issue of the Journal of Diabetes Investigation.

Vitamin B may not reduce risk of memory loss, study says

November 12, 2014
Taking vitamin B12 and folic acid supplements may not reduce the risk of memory and thinking problems after all, according to a new study published in the November 12, 2014, online issue of Neurology, the medical journal ...

Recommended for you

Can't exercise? A hot bath may help improve inflammation, metabolism, study suggests

November 14, 2018
Hot water treatment may help improve inflammation and blood sugar (glucose) levels in people who are unable to exercise, according to a new study. The findings are published ahead of print in the Journal of Applied Physiology.

Diabetic foot ulcers heal quickly with nitric oxide technology

November 12, 2018
Diabetic foot ulcers can take up to 150 days to heal. A biomedical engineering team wants to reduce it to 21 days.

Diabetes drug might also ease heart failure risks

November 12, 2018
(HealthDay)—The diabetes drug Farxiga might do double-duty for patients, helping to ward off another killer, heart failure, new research shows.

Marijuana use tied to serious diabetes complication

November 8, 2018
(HealthDay)—People with type 1 diabetes who use marijuana may double their risk of developing a life-threatening complication, a new study suggests.

Researchers report connection between intestinal bacteria and development of diabetes

November 7, 2018
Researchers at Örebro University have, together with a well-known research team in Denmark, developed a method for studying how metabolism in gut bacteria influences health. Their method will now be published in its entirety ...

Genetic factors tied to obesity may protect against diabetes

November 2, 2018
Some genetic variations linked with obesity actually protect against Type 2 diabetes, heart attack and stroke, new findings suggest.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.