Pancreatic cancer risk linked to weak sunlight

April 30, 2015
Maps depict global incidence rates of pancreatic cancer (per 100,000) and ultraviolet B radiation (watts per square meter). Credit: UC San Diego School of Medicine

Writing in the April 30 online issue of the Journal of Steroid Biochemistry and Molecular Biology, researchers at University of California San Diego School of Medicine report pancreatic cancer rates are highest in countries with the least amount of sunlight. Low sunlight levels were due to a combination of heavy cloud cover and high latitude.

"If you're living at a high latitude or in a place with a lot of heavy cloud cover, you can't make vitamin D most of the year, which results in a higher-than-normal risk of getting pancreatic cancer," said first author Cedric F. Garland, DrPH, adjunct professor in the Department of Family Medicine and Public Health and member of UC San Diego Moores Cancer Center.

"People who live in sunny countries near the equator have only one-sixth of the age-adjusted incidence rate of pancreatic cancer as those who live far from it. The importance of sunlight deficiency strongly suggests - but does not prove - that vitamin D deficiency may contribute to risk of pancreatic cancer."

Limited foods naturally contain vitamin D. Fatty fish, such as salmon and tuna, are good sources; beef liver, cheese and egg yolks provide small amounts. Vitamin D is often added as a fortifying nutrient to milk, cereals and juices, but experts say most people also require additional vitamin D to be produce by the body when skin is directly exposed to sunlight. Specifically, ultraviolet B radiation. Skin exposed to sunshine indoors through a window will not produce vitamin D. Cloudy skies, shade and dark-colored skin also reduce vitamin D production.

The UC San Diego team, led by Garland and Edward D. Gorham, PhD, associate professor, had previously shown that sufficient levels of a metabolite of vitamin D in the serum, known as 25-hydroxyvitamin D was associated with substantially lower risk of breast and colorectal cancer. The current paper is the first to implicate vitamin D deficiency with pancreatic cancer.

Researchers studied data from 107 countries, taking into account international differences and possible confounders, such as alcohol consumption, obesity and smoking. "While these other factors also contribute to risk, the strong inverse association with cloud-cover adjusted sunlight persisted even after they were accounted for," said Garland.

UC San Diego researchers had previously identified an association of high latitude with a higher risk of pancreatic cancer. Garland said the new study advances that finding by showing that an estimate of solar ultraviolet B that has been adjusted for heavy produces an even stronger prediction of risk of .

Pancreatic cancer is the 12th most common cancer in the world, according to World Cancer Research Fund International, with 338,000 new cases diagnosed annually. Incidence rates are highest in North America and Europe; lowest in Africa and Asia. It is the seventh most common cause of death from cancer.

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sblythe
not rated yet Apr 30, 2015
This is interesting, but I wonder if the researchers adjusted risk based on the variable of access to diagnostic services. The countries with a low incidence of pancreatic cancers are primarily third-world countries. Pancreatic cancer strikes hard and kills fast. In many poor countries it most likely is never diagnosed because to diagnose it requires at the minimum a CT scan, although technically a tissue biopsy is required to officially make the diagnosis. Many poor people get sick, lose weight, and die without the "benefit" of CT scans and chemotherapy.
Shapoval
not rated yet May 06, 2015
Pancreatic Cancer, UC San Diego Researchers and Father of Oncology. Because cancer researchers scared they will lose money-2015-2050 due to new anticancer iron-deficiency methods, pancreatic cancer can be hard to treat. Scientific iron/cancer information-1905-2015 is largely distorted. Pancreatic cancer is fundamentally a disease caused by cellular iron overload, the Father of Oncology says. Primary tumors always develop at body sites of excessive iron deposits. Such deposits can be inherited or acquired. Cancer is the result of bad luck. UC San Diego researchers can beat pancreatic cancer. Direct intratumoral injections of iron-deficiency agents (ceramic needles) can successfully eliminate inoperable tumors and metastases. Personalized clinical iron-deficiency methods can successfully neutralize micrometastases and HIV. Cancer can be beaten http://www.medica...s/184826 ; http://medicalxpr...ght.html ; Shapoval

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