ARVO: Genetic link ID'd for strabismus and schizophrenia

May 5, 2015
ARVO: genetic link ID'd for strabismus and schizophrenia

(HealthDay)—There is a genetic link for strabismus and schizophrenia, with almost half of the genes dysregulated in strabismic medial rectus muscle identified as biomarkers for schizophrenia, according to a study presented at the annual meeting of the Association for Research in Vision and Ophthalmology, held from May 3 to 7 in Denver.

Austin J. Christensen, from the University of Nevada School of Medicine in Reno, and colleagues examined the correlation between schizophrenia and strabismus. The authors compared samples of strabismic lateral and medial rectus muscle, obtained during corrective surgeries, and normal samples from deceased organ donors. From paired comparisons (four per condition), they examined consistent differences of two-fold or more on targeted or customized arrays. Gene expression was assessed in 84 of interest based on known risk factors for schizophrenia.

The researchers found that 22 of the 381 genes encoding signaling molecules were dysregulated in strabismic medial rectus muscle versus normal rectus muscle. Ten of these genes were biomarkers for schizophrenia. Overall, 22.6 percent of the schizophrenia-related genes were differentially expressed in the medial rectus muscle, including cytokines, growth factors and their receptors, and downstream signaling pathways.

"Our data establish a molecular link between exotropia and ," the authors write. "This suggests that a combination of defects in signaling molecules is relevant in the pathogenesis of both diseases."

Explore further: An evolutionary approach reveals new clues toward understanding the roots of schizophrenia

More information: Press Release
More Information

Related Stories

An evolutionary approach reveals new clues toward understanding the roots of schizophrenia

February 24, 2015
Is mental illness simply the evolutionary toll humans have to pay in return for our unique and superior cognitive abilities when compared to all other species? But if so, why have often debilitating illnesses like schizophrenia ...

Schizophrenia and cannabis use may share common genes

June 24, 2014
Genes that increase the risk of developing schizophrenia may also increase the likelihood of using cannabis, according to a new study led by King's College London, published today in Molecular Psychiatry.

New technique helps determine degree of muscle wasting in critically ill patients

September 2, 2012
Researchers have identified a new technique that can help determine the severity of muscle loss in critically ill patients. The breakthrough could lead to new research to help prevent muscle-wasting and new therapeutic interventions ...

Experts find epigenetic changes moderate reality distortion in schizophrenia patients

June 10, 2013
A study in Schizophrenia Bulletin is among the first to indicate epigenetic changes related to immune function in schizophrenia. DNA methylation, a process involving the addition of a methyl group to the DNA without changing ...

Aligning the eyes: A simpler surgery for a complex condition

February 13, 2012
People with strabismus (misalignment and limited movement of one or more eyes) are often teased about their crossed-eye appearance; those with more complex, disfiguring strabismus can become socially isolated and develop ...

Researchers identify over 100 locations on the human genome associated with schizophrenia risk

March 4, 2015
An international consortium has combined data from 150,000 people around the globe to shed light on genetic risk factors for schizophrenia, a debilitating psychotic disorder.

Recommended for you

New Tourette disorder genes come to light

September 25, 2018
In the largest DNA sequencing study of Tourette Disorder (TD) to date, UC San Francisco researchers and their collaborators have unearthed new data suggesting a potential role for disruptions in cell polarity in the development ...

Genetic determinants of telomere length in African American youth

September 25, 2018
Telomeres are DNA-protein structures that play a vital role in maintaining DNA stability and integrity. Telomere length (TL) is an important biomarker of aging and overall health, but TL has been mostly studied in adult populations ...

Thousands of unknown DNA changes in the developing brain revealed by machine learning

September 24, 2018
Unlike most cells in the rest of our body, the DNA (the genome) in each of our brain cells is not the same: it varies from cell to cell, caused by somatic changes. This could explain many mysteries—from the cause of Alzheimer's ...

Mitochondrial diseases could be treated with gene therapy, study suggests

September 24, 2018
Researchers have developed a genome editing tool for the potential treatment of mitochondrial diseases: serious and often fatal conditions which affect 1 in 5,000 people.

Height may be risk factor for varicose veins, study finds

September 24, 2018
The taller you are, the more likely you are to develop varicose veins, according to a study led by Stanford University School of Medicine researchers that examined the genes of more than 400,000 people in search of clues ...

How to edit your mitochondria

September 24, 2018
Mitochondrial genetic engineering is the adaptation of genetic engineering techniques to specific mitochondrial problems. Although it is not common to be born with severe mitochondrial issues, we will all eventually have ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.