E-cigarette vapor could lead to emphysema, study finds

E-cigarette vapor could lead to emphysema, study finds

Like tobacco, e-cigarettes affect a smoker's lungs and long-term exposure could lead to chronic obstructive pulmonary disease – more commonly known as COPD or emphysema – according to the latest research by Central Michigan University College of Medicine's Neeraj Vij, an associate professor of molecular and cell biology.

Vij, working with research fellow Prashanth Shivalingappa and CMU seniors Colin Westphal of Linden and Rachel Hole of Oakland, examined how e-cigarette vapor compared to tobacco smoke by testing how the vapor affects cells. The team found even minimal exposure of e-cigarette vapor for one hour, disrupted the protein processes in cells. It is the same path and second-hand smoke takes in our bodies.

The team's e-cigarette findings were published as an abstract in the April edition of the Journal of the Federation of American Societies for Experimental Biology.

"COPD/ is not a genetic disorder," Vij said. "We have described the role of overall protein processing in this and in previous research, which has been confirmed by studies from other groups.

"What we are talking about is how these proteins are made and how they are degraded. This process of proteostasis in our cells has to be very – in layman's terms – tightly regulated, because if it goes off-balance, it's a big problem."

Vij, Shivalingappa, Hole and Westphal exposed human bronchial to e-cigarette vapor from one to six hours and saw "significant disruptions" of the protein processing in the cells. Further tests verified that even minimal exposure of one-hour created harmful changes. The team also confirmed its findings with tests on laboratory mice exposed to acute e-cigarette vapors.

Vij joined the College of Medicine faculty last year from Johns Hopkins University, where he was an assistant professor and his research into inflammation and specific proteins led to a better understanding of possible treatments for cystic fibrosis and COPD. He brought his ongoing research program on molecular pathways that lead to chronic diseases to CMU. His work was initiated by funding from National Institute of Health, Cystic Fibrosis Foundation and the Flight Attendant Medical Research Institute.

Vij's recent research into first- and second-hand smoke exposure related to COPD was published in The American Journal of Respiratory Cell Molecular Biology, Apoptosis and PlosOne and abstracts related to smoke-induced emphysema were published earlier this year by the National Center for Biotechnology Information. He also presented April 1 at the Experimental Biology Conference in Boston.


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Citation: E-cigarette vapor could lead to emphysema, study finds (2015, May 7) retrieved 18 July 2019 from https://medicalxpress.com/news/2015-05-e-cigarette-vapor-emphysema.html
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May 08, 2015
could? so i might not get it?

May 08, 2015
could this , could that , I think this , I think that, that is science?

May 08, 2015
Sheer speculation. In the real world smokers who switch are experiencing massive health benefits. In 5 years vaping I have dropped 90% of asthma meds - not had an attack in that time.
A friend with emphysema has at last switched to e-cigs - where he needed Ventolin twice to get him to the Betting Shop he now needs none! This same story is repeated over and over on social media and Vaping Forums and no, we're not Astroturf or Anecdotes, just real people and not just Petrie dishes.

May 08, 2015
Could get it? I could die from eating a tomato too.

May 08, 2015
Oh goody , another e-cig study funded by big tobacco . How much vape did they subject these poor little mouse lungs to anyways ? I'm sure they would of used a long term vaper's lungs to study if they could of found one that died of COPD .............Well I have real lungs and smoked for 30 years and have been vaping for for almost three years and I can tell you my lungs have never felt better !

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