Microbleeds, diminished cerebral blood flow in cognitively normal older patients

July 13, 2015

A small imaging study suggests cortical cerebral microbleeds in the brain, which are the remnant of red blood cell leakage from small vessels, were associated with reduced brain blood flow in a group of cognitively normal older patients, according to an article published online by JAMA Neurology.

Cerebral microbleeds (CMBs) are a common finding in of elderly patients. Some previous research has suggested an association between CMBs and cognitive deficits, although the mechanism is not clear. Some studies also have suggested CMBs may be related to abnormal , although those abnormalities had not been reported for healthy patients with incidental CMBs.

William E. Klunk, M.D., Ph.D., of the University of Pittsburgh, and colleagues used imaging to study 55 cognitively normal individuals (average age nearly 87) to examine CMBs and cerebral , among other things.

The authors found CMBs in 21 of the 55 participants (38 percent) for a total of 54 CMBs. Cortical CMBs in the brain were associated with reduced cerebral blood flow in multiple regions, according to the results.

"In cognitively normal elderly individuals, incidental CMBs in cortical locations are associated with widespread reduction in resting state-CBF [cerebral blood flow]. Chronic hypoperfusion [insufficient blood flow] may put these people at risk for neuronal injury and neurodegeneration. Our results suggest that resting-state CBF is a marker of CMB-related small-vessel disease," the study concludes.

Explore further: Cerebral blood flow as a possible marker for concussion outcomes

More information: JAMA Neurol. Published online July 13, 2015. DOI: 10.1001/jamaneurol.2015.1359

Related Stories

Cerebral blood flow as a possible marker for concussion outcomes

March 2, 2015
A new imaging study suggests that cerebral blood flow recovery in the brain could be a biomarker of outcomes in patients following concussion, according to a study published online by JAMA Neurology.

COPD increases risk of developing cerebral microbleeds

July 19, 2013
Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of developing cerebral microbleeds, according to a new study from researchers in the Netherlands. Cerebral microbleeds are a marker of cerebral ...

Ability to balance on one leg may reflect brain health and stroke risk

December 18, 2014
Struggling to balance on one leg for 20 seconds or longer was linked to an increased risk for small blood vessel damage in the brain and reduced cognitive function in otherwise healthy people with no clinical symptoms, according ...

Study shows long-term effects of type 2 diabetes on the brain, thinking

July 8, 2015
In just two years, people with type 2 diabetes experienced negative changes in their ability to regulate blood flow in the brain, which was associated with lower scores on tests of cognition skills and their ability to perform ...

Controlling arterial tone and blood flow in the brain

April 27, 2015
Researchers have performed the first human-based study to identify calcium channels in cerebral arteries and determine the distinct role each channel plays in helping control blood flow to the brain. The study appears in ...

Recommended for you

Firing of neurons changes the cells that insulate them

August 22, 2017
Through their pattern of firing, neurons influence the behavior of the cells that upon maturation will provide insulation of neuronal axons, according to a new study publishing 22 August in the open access journal PLOS Biology ...

Activating brain region creates intense desire to use cocaine

August 22, 2017
Researchers have identified a portion of the brain that intensifies one's desire for certain rewards—in this case, mimicking addiction to cocaine.

Study suggests serotonin may worsen tinnitus

August 22, 2017
Millions of people suffer from the constant sensation of ringing or buzzing in the ears known as tinnitus, creating constant irritation for some and severe anxiety for others. Research by scientists at OHSU shows why a common ...

Brain region mediates pleasure of eating

August 22, 2017
Providing the body with food is essential for survival. But even when full, we can still take pleasure in eating. Researchers at the Max Planck Institute of Neurobiology in Martinsried and the Friedrich Miescher Institute ...

Chronic stress induces fatal organ dysfunctions via a new neural circuit

August 22, 2017
Hokkaido University researchers revealed that fatal gut failure in a multiple sclerosis (MS) mouse model under chronic stress is caused by a newly discovered nerve pathway. The findings could provide a new therapeutic strategy ...

Contact in sports may lead to differences in the brains of young, healthy athletes

August 22, 2017
People who play contact sports show changes to their brain structure and function, with sports that have greater risk of body contact showing greater effects on the brain, a new study has found.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.