Optical coherence tomography IDs brain atrophy in MS

July 23, 2015
Optical coherence tomography IDs brain atrophy in MS
Rates of ganglion cell + inner plexiform layer atrophy mirrors that of whole brain atrophy in multiple sclerosis, as measured by optimal coherence tomography, according to a study published online July 18 in the Annals of Neurology.

(HealthDay)—Rates of ganglion cell + inner plexiform layer (GCIP) atrophy mirrors that of whole brain atrophy in multiple sclerosis (MS), as measured by optimal coherence tomography (OCT), according to a study published online July 18 in the Annals of Neurology.

In order to validate the utility of OCT as an indicator of neuronal tissue damage in patients with MS, Shiv Saidha, M.B.B.Ch., from Johns Hopkins University in Baltimore, and colleagues examined whether atrophy of specific retinal layers and brain substructures are associated over time. They performed biannual cirrus high definition OCT in 107 patients with MS.

The researchers observed a between rates of GCIP and whole-brain, gray matter (GM), white matter (WM), and thalamic atrophy. There was a stronger correlation for GCIP and whole- rates in progressive versus relapsing-remitting MS (RRMS) (r = 0.67; P < 0.001 versus r = 0.33; P = 0.007). In RRMS, the correlation between rates of GCIP and whole-brain (and GM and WM) atrophy increased incrementally with step-wise refinement to exclude ON (eyes with a past history of optic neuritis) effects; the correlation increased to 0.45 and 0.60, respectively, excluding eyes and then patients, consistent with effect modification. Lesion accumulation rate correlated with GCIP and inner nuclear layers atrophy rates in RRMS.

"Our findings support OCT for clinical monitoring and as an outcome in investigative trials," the authors write.

Several authors disclosed financial ties to the pharmaceutical and biotechnology industries.

Explore further: Researchers link body temperature to relapsing-remitting MS and fatigue

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Researchers link body temperature to relapsing-remitting MS and fatigue

March 18, 2014
Kessler Foundation researchers have demonstrated for the first time ever that body temperature is elevated endogenously in relapsing-remitting multiple sclerosis (RRMS) and linked to worse fatigue. The article was published ...

Atrophy in key region of brain associated with multiple sclerosis

April 23, 2013
Magnetic resonance imaging (MRI) measurements of atrophy in an important area of the brain are an accurate predictor of multiple sclerosis (MS), according to a new study published online in the journal Radiology. According ...

Quick, cheap retina scan can predict brain damage caused by multiple sclerosis

October 17, 2012
An inexpensive, five-minute eye scan can accurately assess the amount of brain damage in people with the debilitating autoimmune disorder multiple sclerosis (MS), and offer clues about how quickly the disease is progressing, ...

Exercise cuts atrophy, white matter lesion load in elderly

October 24, 2012
(HealthDay)—In older adults, physical activity is associated with less brain atrophy and white matter lesion (WML) load, according to a study published in the Oct. 23 issue of Neurology.

Low diastolic blood pressure may be associated with brain atrophy

June 10, 2013
Low baseline diastolic blood pressure (DBP) appears to be associated with brain atrophy in patients with arterial disease, whenever declining levels of blood pressure (BP) over time among patients who had a higher baseline ...

Simple eye scan opens window to multiple sclerosis

October 15, 2007
A five-minute eye exam might prove to be an inexpensive and effective way to gauge and track the debilitating neurological disease multiple sclerosis, potentially complementing costly magnetic resonance imaging to detect ...

Recommended for you

Motor learning for precise motor execution

September 26, 2018
Scientists at Tokyo Metropolitan Institute of Medical Science, RIKEN, National Center of Neurology and Psychiatry, Nozomi Hospital and Tokyo Medical and Dental University have identified acquisition of two types of internal ...

Diversity in the brain—how millions of neurons become unique

September 26, 2018
How is it possible that so many different and highly specific neuron types arise in the brain? A mathematical model developed by researchers from the University of Basel's Biozentrum demonstrates that different variants of ...

Sensitive babies become altruistic toddlers

September 25, 2018
Our responsiveness to seeing others in distress accounts for variability in helping behavior from early in development, according to a study published September 25 in the open-access journal PLOS Biology by Tobias Grossmann ...

Scientists reverse a sensory impairment in mice with autism

September 25, 2018
Using a genetic technique that allows certain neurons in the brain to be switched on or off, UCLA scientists reversed a sensory impairment in mice with symptoms of autism, enabling them to learn a sensory task as quickly ...

Immune cell pruning of dopamine receptors may modulate behavioral changes in adolescence

September 25, 2018
A study by MassGeneral Hospital for Children (MGHfC) researchers finds that the immune cells of the brain called microglia play a crucial role in brain development during adolescence, but that role is different in males and ...

Why it doesn't get dark when you blink

September 25, 2018
People blink every five seconds. During this brief moment, no light falls on the retina, yet people continue to observe a stable picture of the environment with no intervals of darkness. Caspar Schwiedrzik and Sandrin Sudmann, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.