Researchers link body temperature to relapsing-remitting MS and fatigue

March 18, 2014, Kessler Foundation

Kessler Foundation researchers have demonstrated for the first time ever that body temperature is elevated endogenously in relapsing-remitting multiple sclerosis (RRMS) and linked to worse fatigue. The article was published ahead of print on Feb. 21, 2014 in Archives of Physical Medicine & Rehabilitation. Sumowski J, Leavitt V: Body temperature is elevated and linked to fatigue in relapsing-remitting multiple sclerosis, even without heat exposure.

Researchers measured body temperature in 50 patients with RRMS, 40 matched healthy controls, and 22 patients with secondary progressive MS (SPMS). They looked at whether resting body temperature was elevated in patients with RRMS and whether elevation was linked to fatigue, a prevalent, disabling, and recalcitrant symptom in this population.

"We found that body temperature was elevated among patients with RRMS and linked to worse fatigue," reported Dr. Sumowski, research scientist in Neuropsychology & Neuroscience Research. "Our findings support those of randomized controlled trials of cooling garments and antipyretics, which have been shown to effectively reduce fatigue in MS. More studies are needed to investigate the complex relationships among , body temperature and inflammatory processes in RRMS."

Explore further: Tired all the time: Could undiagnosed sleep problems be making MS patients' fatigue worse?

More information: Paper: DOI: 10.1016/j.apmr.2014.02.004

Recent publications: Sumowski J, Chiaravalloti N, Krch D, et al. Education attenuates the negative impact of traumatic brain injury on cognitive status. Arch Phys Med Rehabil 2013;94(12):2562-4. Retrieval practice is a robust memory aid in memory-impaired patients with multiple sclerosis. Mult Scler 2014;95(2):397-400.

Related Stories

Tired all the time: Could undiagnosed sleep problems be making MS patients' fatigue worse?

February 14, 2014
People with multiple sclerosis (MS) might assume that the fatigue they often feel just comes with the territory of their chronic neurological condition.

MS study correlates fMR with negative effect of warmer weather on cognitive status

October 30, 2013
Kessler Foundation scientists correlated functional magnetic resonance imaging (fMRI) findings with the negative impact of outdoor temperature on cognitive functioning in multiple sclerosis (MS). This study, "Warmer outdoor ...

Study finds aerobic exercise benefits memory in persons with multiple sclerosis

November 1, 2013
A research study headed by Victoria Leavitt, Ph.D. and James Sumowski, Ph.D., of Kessler Foundation, provides the first evidence for beneficial effects of aerobic exercise on brain and memory in individuals with multiple ...

Neuroimaging study sheds light on mechanisms of cognitive fatigue in MS

November 1, 2013
A new study by Kessler Foundation scientists sheds light on the mechanisms underlying cognitive fatigue in individuals with multiple sclerosis. Cognitive fatigue is fatigue resulting from mental work rather than from physical ...

Sodium buildup in brain linked to disability in multiple sclerosis

July 17, 2012
A buildup of sodium in the brain detected by magnetic resonance imaging (MRI) may be a biomarker for the degeneration of nerve cells that occurs in patients with multiple sclerosis (MS), according to a new study published ...

Study identifies biomarker and potential therapy target in multiple sclerosis

January 30, 2013
Researchers from Benaroya Research Institute at Virginia Mason (BRI) have found that proteins in the IL-6 signaling pathway may be leveraged as novel biomarkers of multiple sclerosis (MS) to gauge disease activity and as ...

Recommended for you

A new theory on reducing cardiovascular disease risk in binge drinkers

January 23, 2018
A new study shows that binge drinkers have increased levels of a biomarker molecule—microRNA-21—that may contribute to poor vascular function.

Flu infection study increases understanding of natural immunity

January 23, 2018
People with higher levels of antibodies against the stem portion of the influenza virus hemagglutinin (HA) protein have less viral shedding when they get the flu, but do not have fewer or less severe signs of illness, according ...

New long-acting approach for malaria therapy developed

January 22, 2018
A new study, published in Nature Communications, conducted by the University of Liverpool and the Johns Hopkins University School of Medicine highlights a new 'long acting' medicine for the prevention of malaria.

Virus shown to be likely cause of mystery polio-like illness

January 22, 2018
A major review by UNSW researchers has identified strong evidence that a virus called Enterovirus D68 is the cause of a mystery polio-like illness that has paralysed children in the US, Canada and Europe.

Creation of synthetic horsepox virus could lead to more effective smallpox vaccine

January 19, 2018
UAlberta researchers created a new synthetic virus that could lead to the development of a more effective vaccine against smallpox. The discovery demonstrates how techniques based on the use of synthetic DNA can be used to ...

Study ends debate over role of steroids in treating septic shock

January 19, 2018
The results from the largest ever study of septic shock could improve treatment for critically ill patients and save health systems worldwide hundreds of millions of dollars each year.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.