Calculated LDL-C varies at lower values of measured LDL-C

Calculated LDL-C varies at lower values of measured LDL-C

(HealthDay)—At lower values of measured low-density lipoprotein cholesterol (LDL-C), the variation and bias of calculated LDL-C increases, according to a study published in the Aug. 15 issue of The American Journal of Cardiology.

Noting that the Friedewald equation for calculation of LDL-C is the primary laboratory method for routine LDL-C measurement, Jeffrey W. Meeusen, Ph.D., from the Mayo Clinic in Rochester, Minn., and colleagues compared the accuracy and of calculated LDL-C <130 mg/dL to LDL-C measured by β quantification (considered the gold standard). The comparison was conducted in 15,917 patients with fasting triglyceride concentrations <400 mg/dL.

The researchers found that at lower values of measured LDL-C, variation and bias of calculated LDL-C increased. For a calculated LDL-C of 70 mg/dL and 30 mg/dL, the 95 percent confidence intervals were 60 to 86 mg/dL and 24 to 60 mg/dL, respectively.

"Calculated LDL-C <30 mg/dL (0.8 mmol/L) should not be reported because of significant deviation from the gold standard measured LDL-C results, and caution is advised when using calculated LDL-CF values <70 mg/dL (1.8 mmol/L) to make treatment decisions," the authors write.


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Citation: Calculated LDL-C varies at lower values of measured LDL-C (2015, August 11) retrieved 23 January 2020 from https://medicalxpress.com/news/2015-08-ldl-c-varies-values.html
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