Nature of beta-cell failure tied to glycemic response to GLP-1RA

Nature of β-cell failure tied to glycemic response to GLP-1RA

(HealthDay)—In patients with type 2 diabetes, characteristics and biomarkers of β-cell failure are associated with glycemic response to GLP-1 receptor agonist (GLP-1RA) therapy, according to a study published online Aug. 4 in Diabetes Care.

Angus G. Jones, M.B.B.S., from the University of Exeter Medical School in the United Kingdom, and colleagues examined whether clinical characteristics and simple biomarkers of β-cell failure correlate with individual variation in glycemic response to GLP-1RA therapy. Six hundred twenty participants with and hemoglobin A1c (HbA1c) ≥7.5 percent commencing GLP-1RA therapy were studied prospectively and their response to therapy was assessed over six months.

The researchers observed a correlation between reduced glycemic response to GLP-1RAs and longer duration , insulin cotreatment, lower fasting C-peptide, lower post-meal urine C-peptide-to-creatinine ratio, and positive GAD or IA2 islet autoantibodies (all P ≤ 0.01). Markedly reduced glycemic response to GLP-1RA therapy was seen for participants with positive autoantibodies (mean HbA1c change, −0.5 versus −1.4 percent; P = 0.005) or severe insulin deficiency (C-peptide <0.25 nmol/L, mean change −0.2 versus −1.4 percent; P = 0.002). These markers were mainly seen in insulin-treated participants and did not correlate with weight change.

"Clinical markers of low β-cell function are associated with reduced glycemic response to GLP-1RA therapy," the authors write. "C-peptide and islet autoantibodies represent potential biomarkers for the stratification of GLP-1RA in insulin-treated diabetes."


Explore further

Proof-of-concept study to assess impact of glycemic variability

More information: Abstract
Full Text (subscription or payment may be required)
Journal information: Diabetes Care

Copyright © 2015 HealthDay. All rights reserved.

Citation: Nature of beta-cell failure tied to glycemic response to GLP-1RA (2015, August 10) retrieved 12 December 2019 from https://medicalxpress.com/news/2015-08-nature-beta-cell-failure-tied-glycemic.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
5 shares

Feedback to editors

User comments