Veterans have poor oral, throat cancer outcomes

August 24, 2015

Veterans have poor oral, throat cancer outcomes
(HealthDay)—In veterans, oropharyngeal squamous cell carcinoma (SCC) is associated with traditional carcinogens and poor clinical outcomes, according to a study published in the September issue of Head & Neck.

Vlad C. Sandulache, M.D., Ph.D., from the Baylor College of Medicine in Houston, and colleagues evaluated patient, tumor, and treatment characteristics for 200 treated for oropharyngeal SCC between 2000 and 2012.

The researchers found that most patients (77 percent) were white and heavy smokers. During treatment, 27 patients required tracheostomy and 63 required gastrostomy placement. At five years, overall survival (OS) was 40 percent. T classification, treatment intensity, completion of treatment, and p16 tumor status all impacted survival. Completion of a treatment regimen consistent with National Comprehensive Cancer Network guidelines was unattainable by almost 30 percent of patients.

"Oropharyngeal SCC in veterans is associated with traditional carcinogens and poor ," the authors write. "Careful consideration must be given to improving treatment paradigms for this cohort given their limited tolerance for treatment escalation."

Explore further: Two cases of SCC described after ingenol mebutate gel application

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Two cases of SCC described after ingenol mebutate gel application

August 10, 2015
(HealthDay)—Two cases of squamous cell carcinoma (SCC) have been described, with rapid onset after application of ingenol mebutate gel for treatment of actinic keratosis (AK). The report was published online July 31 in ...

Periodontitis linked to HPV-positive head, neck tumors

June 20, 2012
(HealthDay) -- For patients with head and neck squamous cell carcinoma (HNSCC) there is an increased risk of human papillomavirus (HPV)-positive tumors among those with a history of periodontitis, according to a study published ...

Study examines chronic inflammation in oral cavity and HPV status of head and neck cancers

June 18, 2012
Among patients with head and neck squamous cell carcinomas, a history of chronic inflammation in the mouth (periodontitis, i.e. gum disease) may be associated with an increased risk of tumors positive for human papillomavirus ...

Prognostic factors identified for peripheral squamous cell carcinomas of the lung

October 24, 2014
A better survival outcome is associated with low blood levels of squamous cell carcinoma antigen, or absence of tumor invasion either into the space between the lungs and chest wall or into blood vessels of individuals with ...

Blood antibodies may predict HPV-positive oropharyngeal cancer survival

June 15, 2015
The presence of certain human papillomavirus (HPV)-16 antibodies in the blood was associated with improved rates of survival among patients with HPV-related oropharyngeal carcinoma.

Superficial X-ray viable for basal, squamous cell carcinoma

August 6, 2012
(HealthDay) -- Superficial X-ray therapy remains a viable treatment for primary basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in select patients, according to a study published online July 23 in the Journal ...

Recommended for you

Mutant cells colonize our tissues over our lifetime

October 18, 2018
By the time we reach middle age, more than half of the oesophagus in healthy people has been taken over by cells carrying mutations in cancer genes, scientists have uncovered. By studying normal oesophagus tissue, scientists ...

Study involving hundreds of patient samples may reveal new treatment options of leukemia

October 17, 2018
After more than five years and 672 patient samples, an OHSU research team has published the largest cancer dataset of its kind for a form of leukemia. The study, "Functional Genomic Landscape of Acute Myeloid Leukemia", published ...

A 150-year-old drug might improve radiation therapy for cancer

October 17, 2018
A drug first identified 150 years ago and used as a smooth-muscle relaxant might make tumors more sensitive to radiation therapy, according to a recent study led by researchers at The Ohio State University Comprehensive Cancer ...

Loss of protein p53 helps cancer cells multiply in 'unfavourable' conditions

October 17, 2018
Researchers have discovered a novel consequence of loss of the tumour protein p53 that promotes cancer development, according to new findings in eLife.

Researcher fighting breast cancer with light therapy

October 17, 2018
When treatment is working for a patient who is fighting cancer, the light at the end of the tunnel is easier to see.

New method uses just a drop of blood to monitor lung cancer treatment

October 17, 2018
Dr. Tasuku Honjo won the 2018 Nobel Prize in physiology or medicine for discovering the immune T-cell protein PD-1. This discovery led to a set of anti-cancer medications called checkpoint inhibitors, one of the first of ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.