Weight loss benefits NASH, no matter how it's done

August 24, 2015

Weight loss benefits NASH, no matter how it's done
(HealthDay)—Weight loss can improve nonalcoholic steatohepatitis (NASH) in obese or overweight people, whether excess pounds are shed through lifestyle changes or weight-loss surgery, according to research published in the August issue of Gastroenterology.

In one study, researchers found that overweight and who achieved a weight loss of 10 percent or more after one year of involving a low-calorie diet and exercise experienced reductions in nonalcoholic fatty liver disease activity score. In addition, 90 percent experience resolution of NASH, and 45 percent showed regression of fibrosis. Weight loss of 7 to 10 percent also reduced disease severity in some patients, including men and those without diabetes.

In the other study, researchers found that NASH disappeared in 85 percent of obese patients one year after they had . The success rate was higher among those with mild NASH (94 percent) than among those with severe disease (70 percent).

"In summary, we have now evidence that weight loss may promote NASH regression, possibly altering the natural history of disease," Giulio Marchesini, M.D., of the University of Bologna, Italy, and colleagues write in an editorial accompanying the studies. "We need to make people more aware of the risks of obesity-associated NASH, and validated weight-reducing strategies should be offered to all patients; behavior therapy, drugs, and surgery should be integrated with each other and with societal interventions, aimed at decreasing the obesiogenic environment. The final recipe is for healthy liver!"

Explore further: Weight loss for a healthy liver

More information: Abstract 1
Full Text
Abstract 2
Full Text
Editorial

Related Stories

Weight loss for a healthy liver

July 27, 2015
Weight loss through both lifestyle modification and bariatric surgery can significantly reduce features of nonalcoholic steatohepatitis (NASH), a disease characterized by fat in the liver, according to two new studies published ...

Drug helps patients with diabetes lose weight

August 18, 2015
Among overweight and obese patients with type 2 diabetes, daily injection of the diabetes drug liraglutide with a modified insulin pen device, in addition to diet and exercise, resulted in greater weight loss over 56 weeks ...

Researchers link liver disease and drug metabolism

July 9, 2015
Researchers at the University of Arizona College of Pharmacy have discovered that nonalcoholic steatohepatitis (NASH), an increasingly common but often undiagnosed liver disease, could have significant medical implications ...

New study indicates that exercise improves non-alcoholic fatty liver disease

April 8, 2015
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the western world. A new study published in the Journal of Hepatology shows that exercise, regardless of frequency or intensity, ...

'Thrifty phenotype' leads to less weight loss in obese

August 1, 2015
(HealthDay)—For obese individuals, energy expenditure during fasting and response to overfeeding predict weight loss in response to caloric restriction, according to a study published in the August issue of Diabetes.

NASH associated with a 50 percent higher chance of death compared with NAFLD

April 24, 2015
Results from a large population-based cohort of almost a million people in the UK found that the chances of dying from non-alcoholic steatohepatitis (NASH), over a 14-year period, was approximately 50% higher than for those ...

Recommended for you

A guide to Acute flaccid myelitis (AFM), the rare, polio-like illness making young children sick

October 22, 2018
A fast-acting, polio-like illness has sickened 62 young children, with an average age of 4, in 22 U.S. states so far this fall.

Consuming caffeine from coffee reduces incident rosacea

October 22, 2018
(HealthDay)—Caffeine intake from coffee is inversely associated with the risk for incident rosacea, according to a study published online Oct. 17 in JAMA Dermatology.

Home-based biofeedback therapy is effective option for tough-to-treat constipation

October 22, 2018
Biofeedback therapy used at home is about 70 percent effective at helping patients learn how to coordinate and relax bowel muscles and relieve one of the most difficult-to-treat types of constipation, investigators report.

New hope for cystic fibrosis

October 19, 2018
A new triple-combination drug treatment being trialled at the Mater Hospital in Brisbane could increase the life expectancy of patients with cystic fibrosis.

Bug guts shed light on Central America Chagas disease

October 18, 2018
In Central America, Chagas disease, or American trypanosomiasis, is spread by the "kissing bug" Triatoma dimidiata. By collecting DNA from the guts of these bugs, researchers reporting in PLOS Neglected Tropical Diseases ...

Rapid genomic sequencing of Lassa virus in Nigeria enabled real-time response to 2018 outbreak

October 18, 2018
Mounting a collaborative, real-time response to a Lassa fever outbreak in early 2018, doctors and scientists in Nigeria teamed up with researchers at Broad Institute of MIT and Harvard and colleagues to rapidly sequence the ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.