Dextromethorphan plus sitagliptin promising in type 2 diabetes

Dextromethorphan + sitagliptin promising in type 2 diabetes

(HealthDay)—Dextromethorphan combined with sitagliptin shows potential for treatment of type 2 diabetes mellitus, according to a study published online Sept. 12 in Diabetes, Obesity and Metabolism.

Jan Marquard, M.D., from Heinrich Heine University in Germany, and colleagues examined the blood-glucose-lowering effects of 30, 60, and 90 mg dextromethorphan as well as 100 mg sitagliptin alone versus combinations of dextromethorphan and sitagliptin during an oral glucose tolerance test (OGTT). Participants consisted of 20 males with type 2 .

The researchers found that the strongest effect in the OGTT was seen with the combination of 60 mg dextromethorphan plus 100 mg sitagliptin. Maximum blood glucose concentrations were lowered with this combination. In addition the baseline-adjusted area under the curve of serum insulin concentrations was increased in the first 30 minutes of the OGTT to a significantly larger extent than with 100 mg sitagliptin alone (P < 0.05) or placebo (P < 0.001). All study drugs, alone or in combination, were tolerated, with no evidence of serious adverse events or hypoglycemia.

"Long-term clinical trials are now warranted to investigate the potential of the combination of 30 or 60 mg dextromethorphan and dipeptidyl peptidase-4 inhibitors in the treatment of individuals with type 2 mellitus, in particular since preclinical studies revealed beta cell protective properties of dextromethorphan," the authors write.

Three study authors are pursuing a patent titled "Morphinan-derivatives for treating diabetes and related disorders."

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Sep 22, 2015
This may be relevant:
Possible antimicrobial action of Dextromethorphan playing a role:



Sep 23, 2015
I... implement David Andrew's methods the very next day. I've lost over..
I know I am probably answering a bot, but the Newcastle university study that is the basis of Andrew's method is free. It is basically a low caloric intake diet to simulate gastric bypass surgery:

The standard approach would involve:
a) Decreasing total food (and alcohol) intake by about one half
b) Using smaller plates
c) Eating more slowly
d) Recognising that the sensation of hunger is sign of success, not a signal to eat
e) Enjoy that hunger. Celebrate with a glass of water; maybe fizzy water
However, if a person finds this difficult, the liquid meal approach could be used.

Sep 23, 2015
This may be relevant:
Possible antimicrobial action of Dextromethorphan playing a role:


That may be bit of a leap. The dosage in mice were: "Dextromethorphan (12.5 mg/kg) was intraperitoneally administrated to mice". The equivalent dose in humans would be about 750 mg of dextromethorphan (DX). But DX could certainly be interfering with the intestinal biome and exerting its effect there.

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