Plant extract from traditional Indian medicine may fight blood cancer

Plant extract from traditional Indian medicine may fight blood cancer

A University of Kentucky study shows that withaferin A, a component of Withania somnifera (winter cherry) plant extract, may hold promise as a new treatment for non-Hodgkin's lymphoma.

Winter cherry extract was used in traditional Ayurvedic Indian medicine for thousands of years before it caught the interest of Subbarao Bondada, a University of Kentucky College of Medicine professor and researcher for the UK Markey Cancer Center. Because withaferin A shows promise in treating other cancers without the side effects associated with current treatments, Bondada's laboratory tested it against lymphoma. Non-Hodgkin's lymphoma is one of the most common cancers in the U.S. and is known for being particularly aggressive.

Unlike other studies using withaferin A to treat cancer, Bondada's study, published in the journal Cancer Biology and Therapy, is the first to test the chemical against a blood cancer. Previous studies using withaferin A focused on cancers producing tumors that grow as a mass in tissue, more commonly known as solid tumors.

Katie McKenna, a graduate student in Bondada's laboratory, found that withaferin A prevented the from dividing and ultimately killed them. Specifically, they found withaferin A directly targeted a signaling pathway in the it needs to survive.

"It may be possible to develop orally administered versions of withaferin A that could be used in with fewer side effects than current chemotherapy regimens," Bondada said.

Because withaferin A shows promise in treating non-Hodgkin , Bondada's team is now testing the chemical on chronic lymphocytic leukemia cells.


Explore further

Cancer scan could remove need for radiotherapy for cured patients

Citation: Plant extract from traditional Indian medicine may fight blood cancer (2015, September 14) retrieved 30 November 2021 from https://medicalxpress.com/news/2015-09-traditional-indian-medicine-blood-cancer.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
323 shares

Feedback to editors