African-Americans more likely to develop Alzheimer's disease than Caucasians

December 18, 2015 by Robin Reese, Emory University

Emory University researchers have conducted the only known meta-analysis of Alzheimer's disease (AD) incidence by race and found that African-Americans are 64 percent more likely to develop AD than Caucasians, after adjusting for age, gender and education. The estimate for prevalence of AD was 5.5 percent for Caucasians and 8.6 percent for African-Americans.

The article detailing the findings is scheduled for publication in the Journal of Alzheimer's Disease on Jan. 5, 2016.

Lead author Kyle Steenland, PhD, a professor of environmental and epidemiology at Emory's Rollins School of Public Health, worked with researchers from the Emory Alzheimer's Disease Research Center to analyze data from six U.S. population-based studies to determine incidence and prevalence by race, with a combined 370 African-American and 640 Caucasian incident cases.

"It is generally accepted that African-Americans have higher incidence and prevalence of Alzheimer's , but there has been no quantitative estimate of the higher incidence", says Steenland. "A 64 percent higher incidence among African-Americans is quite a large difference, in our view. We wanted to come up with an overall estimate of racial differences to help motivate further exploration of possible causes, such as biological, psychological and socioeconomic factors."

Steenland says the data could have an impact on the burden related to AD due to projected population increases in those 65 and older, as well as an overall shift in demography with non-whites, who are at higher risk, constituting the majority of the U.S. population by 2045.

Explore further: Researchers identify potential gene that may increase risk of ad in African Americans

More information: A Meta-Analysis of Alzheimer's Disease Incidence and Prevalence Comparing African-Americans and Caucasians. Journal of Alzheimer's Disease, vol. Preprint, no. Preprint, pp. 1-6, 2015
DOI: 10.3233/JAD-150778

Related Stories

Researchers identify potential gene that may increase risk of ad in African Americans

August 4, 2014
Researchers from Boston University School of Medicine (BUSM) report that two rare variants in the AKAP9 gene significantly increase the risk of Alzheimer's disease (AD) in African-Americans.

Alzheimer's may affect the brain differently in African-Americans than European-Americans

July 15, 2015
Alzheimer's disease may cause different changes in the brain, or pathologies, in African-Americans than in white Americans of European descent, according to a study published in the July 15, 2015, online issue of the medical ...

Blood phosphorus levels can help predict kidney failure risk in African-Americans

November 17, 2015
An increase in serum phosphorus levels in African Americans with chronic kidney disease (CKD) is associated with faster progression to kidney failure, known as end-stage renal disease (ESRD), according to new research presented ...

Number of new cases of dementia decreasing for African-Americans but not Africans

August 4, 2015
An Indiana University and Regenstrief Institute study is the first to report significantly decreased incidence rates over two decades for Alzheimer's disease and other dementias in African-Americans. The study is also the ...

Alzheimer's disease may be more prevalent and manifests itself differently among African-Americans

April 7, 2014
A new study by researchers at Rush University Medical Center reviews research that suggests that the risk for developing Alzheimer's disease among older African Americans may be two to three times greater than in the non-Hispanic ...

Kidney disease progresses faster in African Americans than other races

November 29, 2012
Among individuals with chronic kidney disease (CKD), African Americans experience faster progression of the disease during later stages compared with other races, according to a study appearing in an upcoming issue of the ...

Recommended for you

Scientists discover why some people with brain markers of Alzheimer's have no dementia

August 16, 2018
A new study from The University of Texas Medical Branch at Galveston has uncovered why some people that have brain markers of Alzheimer's never develop the classic dementia that others do. The study is now available in the ...

Researchers identify new genes that may contribute to Alzheimer's disease

August 14, 2018
Researchers from Boston University School of Medicine, working with scientists across the nation on the Alzheimer's Disease Sequencing Project (ADSP), have discovered new genes that will further current understanding of the ...

Deaths from resident-to-resident incidents in dementia offers insights to inform policy

August 14, 2018
Analyzing the incidents between residents in dementia in long-term care homes may hold the key to reducing future fatalities among this vulnerable population, according to new research from the University of Minnesota School ...

Scientists propose a new lead for Alzheimer's research

August 14, 2018
A University of Adelaide-led team of scientists has suggested a potential link between iron in our cells and the rare gene mutations that cause Alzheimer's disease, which could provide new avenues for future research.

Eye conditions provide new lens screening for Alzheimer's disease

August 8, 2018
Alzheimer's disease is difficult to diagnose as well as treat, but researchers now have a promising new screening tool using the window to the brain: the eye.

Potential indicator for the early detection of dementias

August 7, 2018
Researchers at the University of Basel have discovered a factor that could support the early detection of neurodegenerative diseases such as Alzheimer's or Parkinson's. This cytokine is induced by cellular stress reactions ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.