Lower live birth rate with minimal stimulation IVF

Lower live birth rate with minimal stimulation IVF

(HealthDay)—Minimal stimulation in vitro fertilization (mini-IVF) is associated with reduced live birth rates compared with conventional IVF, according to a study published in the January issue of the American Journal of Obstetrics & Gynecology.

John J. Zhang, M.D., Ph.D., from the New Hope Fertility Center in New York City, and colleagues performed a randomized noninferiority controlled trial, with a prespecified 10 percent border, comparing one cycle of mini-IVF with single embryo transfer with one cycle of conventional IVF with double embryo transfer. A total of 564 couples (women aged <39 years) who were undergoing their first IVF cycle were randomized to mini-IVF (285 couples) or conventional IVF (279 couples).

The researchers found that the cumulative live birth rates were 49 and 63 percent for mini-IVF and conventional IVF, respectively (relative risk, 0.76). Ovarian hyperstimulation syndrome did not occur after mini-IVF, compared with 5.7 percent of cases after conventional IVF. The multiple pregnancy rates were 6.4 and 32 percent, respectively, in mini-IVF and conventional IVF (relative risk, 0.25). Compared with conventional IVF, gonadotropin use was significantly lower with mini-IVF (P < 0.0001).

"How these different dimensions are weighed by couples who are deciding between mini-IVF or conventional IVF and whether the lower live birth rate could be offset by a series of 'lower cost' mini-IVF cycles should be the subject of future studies," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Copyright © 2016 HealthDay. All rights reserved.

Citation: Lower live birth rate with minimal stimulation IVF (2016, January 14) retrieved 24 February 2024 from https://medicalxpress.com/news/2016-01-birth-minimal-ivf.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

In vitro fertilization using frozen eggs associated with lower live birth rates


Feedback to editors