Alcohol exposure before birth may later amplify neurological problems from stroke

February 17, 2016, American Heart Association

Exposure to alcohol before birth might impair kidney blood flow in adulthood and heighten neurological problems caused by a stroke, according to an animal study presented at the American Stroke Association's International Stroke Conference 2016.

A research team from Texas A&M Health Science Center, College of Medicine, administered ethanol to six pregnant mice twice daily for four days, from gestational day 12 through 15, and administered water to six other pregnant mice. At 12 days of gestation, the mice were in a stage of pregnancy comparable to late in the first trimester for humans, researchers said.

Using ultrasound testing, the team measured blood flow in both male and female offspring of the mice at 3 months of age, a period equivalent to young in humans. Blood flow analysis showed evidence for increased arterial resistance within the kidneys—a sign of possible early onset renal hypertension—in the male offspring that were exposed to before birth.

Researchers then assessed neurological damage caused by stroke in both male and female offspring and found greater levels of impairment in the six female and six male mice that had fetal alcohol , compared with the dozen that were not exposed to alcohol.

Measurements of the stroke-damaged area of the brain were correlated to scores on neurological testing in the females, but not the males, with fetal alcohol exposure. "The finding indicates that in mice exposed to alcohol before , sex appears to play some role in whether the volume of damaged tissue in the brain correlates with functional and neurological impairment," said lead researcher Shameena Bake, Ph.D., and assistant professor at Texas A&M Health Science Center in Bryan, Texas.

Explore further: Impact of high fructose on health of offspring

Related Stories

Impact of high fructose on health of offspring

February 4, 2016
In a study to be presented on Feb. 5 in the oral session at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, in Atlanta, researchers will present findings on the effects of antenatal exposure ...

Researchers hone in on why female newborns are better protected from brain injury

February 4, 2016
Each year, thousands of newborn babies suffer complications during pregnancy or birth that deprive their brains of oxygen and nutrient-rich blood and result in brain injury. This deprivation results in hypoxic ischemic encephalopathy ...

Millions of pregnant women put their babies at risk with alcohol: CDC

February 2, 2016
(HealthDay)—Drinking before and during pregnancy can cause lifelong physical, behavioral and mental problems for a child. Yet more than 3 million U.S. women risk exposing their baby to alcohol, federal health officials ...

Dad's alcohol consumption could influence sons' drinking, study finds

June 4, 2014
Even before conception, a son's vulnerability for alcohol use disorders could be shaped by a father who chronically drinks to excess, according to a new animal study from the University of Pittsburgh School of Medicine. The ...

Can drinking alcohol harm the child before the mother knows she is pregnant?

May 13, 2015
Alcohol drunk by a mouse in early pregnancy changes the way genes function in the brains of the offspring, shows the recent study conducted at the University of Helsinki. The early exposure was also later apparent in the ...

Low-level arsenic exposure before birth associated with early puberty and obesity

August 26, 2015
Female mice exposed in utero, or in the womb, to low levels of arsenic through drinking water displayed signs of early puberty and became obese as adults, according to scientists from the National Institutes of Health. The ...

Recommended for you

'Good cholesterol' may not always be good

July 19, 2018
Postmenopausal factors may have an impact on the heart-protective qualities of high-density lipoproteins (HDL) - also known as 'good cholesterol' - according to a study led by researchers in the University of Pittsburgh Graduate ...

Using adrenaline in cardiac arrests results in less than 1 percent more people leaving hospital alive

July 18, 2018
A clinical trial of the use of adrenaline in cardiac arrests has found that its use results in less than 1% more people leaving hospital alive—but almost doubles the risk of severe brain damage for survivors of cardiac ...

Omega 3 supplements have little or no heart or vascular health benefit: review

July 17, 2018
New evidence published today shows there is little or no effect of omega 3 supplements on our risk of experiencing heart disease, stroke or death.

Researchers discover new genes associated with heart function

July 17, 2018
A new study from an international research team, led by Dr. Yalda Jamshidi at St George's, University of London, has identified new genes associated with heart function and development.

Southern diet could be deadly for people with heart disease

July 12, 2018
People with a history of heart disease who eat a traditional Southern diet are more likely to die than those who follow a Mediterranean dietary pattern, according to new research.

Late-life high blood pressure may harm the brain, study says

July 11, 2018
Decades ago, hundreds of nuns and priests made an extraordinary decision: They agreed to donate their brains upon death to science, hoping to help solve mysteries about Alzheimer's and other diseases. Now, a study that used ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.