Curcumin may help prevent liver damage from acetaminophen

Curcumin may help prevent liver damage from acetaminophen

(HealthDay)—Curcumin exerts a hepatoprotective effect against acetaminophen-induced damage in mice, according to an experimental study published in the February issue of the Journal of Pharmacy and Pharmacology.

Luis Fernando Granados-Castro, from the National Autonomous University of Mexico in University City, and colleagues evaluated the effect of curcumin (35, 50 or 100 mg/kg) on acetaminophen-induced mitochondrial alterations in the livers of mice. Curcumin was received 90 minutes before acetaminophen injection (350 mg/kg).

The researchers found that in a dose-dependent manner, curcumin prevented acetaminophen-induced liver . Curcumin (100 mg/kg) lessened acetaminophen-induced liver histological damage and increment in plasma alanine aminotransferase and aspartate aminotransferase activity. Additionally, curcumin reduced the decrease in oxygen consumption measured using either succinate or malate/glutamate as substrates (evaluated by state 3, respiratory control ratio, uncoupled respiration, and adenosine diphosphate/oxygen ratio), in membrane potential; in ATP synthesis; in aconitase activity; and in the activity of respiratory complexes I, III, and IV.

"These results indicate that the protective effect of curcumin in acetaminophen-induced hepatotoxicity is associated with attenuation of ," the authors write.


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Curcumin cuts acetaminophen-induced hepatotoxicity in mice

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Citation: Curcumin may help prevent liver damage from acetaminophen (2016, February 25) retrieved 18 July 2019 from https://medicalxpress.com/news/2016-02-curcumin-liver-acetaminophen.html
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