Ezetimibe/Simvastatin ups clinical outcomes in IMPROVE-IT

Ezetimibe/Simvastatin ups clinical outcomes in IMPROVE-IT

(HealthDay)—Lipid-lowering therapy with ezetimibe plus simvastatin is associated with improved clinical outcomes, with a reduction in total primary end point (PEP) events, according to a study published in the Feb. 2 issue of the Journal of the American College of Cardiology.

Noting that ezetimibe/simvastatin therapy in the Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) significantly reduced the first PEPs in patients after , Sabina A. Murphy, M.P.H., from Brigham and Women's Hospital in Boston, and colleagues examined whether total PEP events would also be reduced. They examined all PEP events during a median of six years of follow-up in 18,144 patients randomized to ezetimibe/simvastatin or placebo/simvastatin.

The researcher found that there were 9,545 total PEP events (56 percent first events; 44 percent subsequent events). Compared with placebo/simvastatin, there was a reduction in total PEP events with ezetimibe/simvastatin (incidence-rate ratio [RR], 0.91; P = 0.007), and reductions in the three pre-specified secondary composite end points and the exploratory composite end point of cardiovascular (CV) death, myocardial infarction (MI), or stroke (RR, 0.88; P = 0.002). Decreases in total nonfatal MI and total nonfatal stroke drove the reduction in total events (RRs, 0.87 [P = 0.004] and 0.77 [P = 0.005], respectively).

"These data support continuation of intensive combination lipid-lowering after an initial CV event," the authors write.

Several authors disclosed financial ties to biopharmaceutical companies, including Merck, which manufactures ezetimibe/simvastatin and funded the IMPROVE-IT study.

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Citation: Ezetimibe/Simvastatin ups clinical outcomes in IMPROVE-IT (2016, February 1) retrieved 21 January 2021 from https://medicalxpress.com/news/2016-02-ezetimibesimvastatin-ups-clinical-outcomes-improve-it.html
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