Protecting the heart: Cardiac heme oxygenase regulates injury response

February 25, 2016, Journal of Clinical Investigation

The constant beating of the heart requires an enormous output of energy. To meet this demand, cardiomyocytes are loaded with mitochondria, organelles that generate the majority of energy for cells. These mitochondria are dynamically regulated to ensure that damaged mitochondria are removed and replaced by healthy mitochondria.

In this month's issue of JCI Insight, James George, Anupam Agarwal, and colleagues at the University of Alabama at Birmingham examined the role of the inducible stress response gene heme oxygenase-1 in mediating mitochondrial quality control in the heart.

The research team found that overexpression of human heme oxygenase-1 in mice protected animals from dilated cardiomyopathy induced by the mitochondrial toxin doxorubicin.

Additionally, heme oxygenase-1 overexpression reduced and promoted the generation of new . Cumulatively, this study demonstrates the importance of heme oxygenase-1 in controlling in the heart.

Explore further: Host protein levels correlate with HIV-associated neurocognitive disorder

More information: Travis D. Hull et al. Heme oxygenase-1 regulates mitochondrial quality control in the heart, JCI Insight (2016). DOI: 10.1172/jci.insight.85817

Related Stories

Host protein levels correlate with HIV-associated neurocognitive disorder

September 9, 2014
Combination antiretroviral therapy has dramatically increased the life expectancy for HIV-infected patients. However, the prevalence of HIV-associated neurocognitive disorders, which may be triggered by inflammation in the ...

Doxorubicin-associated mitochondrial iron accumulation promotes cardiotoxicity

January 2, 2014
Doxorubicin is a widely used as a component of chemotherapy regimes; however, the use of doxorubicin is associated with severe cardiotoxicity. It is unclear exactly how doxorubicin promotes cardiotoxicity, but it has been ...

How the cell's power station survives attacks

January 14, 2016
Mitochondria, the power generators in our cells, are essential for life. When they are under attack—from poisons, environmental stress or genetic mutations—cells wrench these power stations apart, strip out the damaged ...

Key protein drives 'power plants' that fuel cells in heart and other key body systems

August 4, 2015
Case Western Reserve University scientists have discovered that a protein called Kruppel-like Factor 4 (KLF4) controls mitochondria—the "power plants" in cells that catalyze energy production. Specifically, they determined ...

Mitochondria trigger cell aging, study shows

February 4, 2016
An international team of scientists has for the first time shown that mitochondria, the batteries of the cells, are essential for ageing.

Recommended for you

A better clot-buster drug for strokes?

April 26, 2018
(HealthDay)—After a stroke, many patients are given the clot-busting intravenous drug alteplase, but another drug may be more effective, Australian researchers report.

Imaging may allow safe tPA treatment of patients with unwitnessed strokes

April 25, 2018
A study led by Massachusetts General Hospital (MGH) investigators may lead to a significant expansion in the number of stroke patients who can safely be treated with intravenous tPA (tissue plasminogen activator), the "clot ...

Mice make over four times as many new heart muscle cells when they exercise, study finds

April 25, 2018
Doctors, health organizations, and the Surgeon General all agree that exercise is good for the heart—but the reasons why are still not well understood.

Heart disease may only be a matter of time for those with healthy obesity

April 24, 2018
People who are 30 pounds or more overweight may want to slim down a bit even if they don't have high blood pressure or any other heart disease risk, according to scientists at Wake Forest Baptist Medical Center.

Women at greater risk of stress-induced ischemia after heart attacks

April 24, 2018
Women who've previously experienced a heart attack have twice the risk of later myocardial ischemia provoked by mental stress when compared to men with a similar history, according to a study published in Circulation.

A wearable device intervention to increase exercise in peripheral artery disease

April 24, 2018
A home-based exercise program, consisting of wearable devices and telephone coaching, did not improve walking ability for patients with peripheral artery disease, according to a new Northwestern Medicine study.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.