Protecting the heart: Cardiac heme oxygenase regulates injury response

February 25, 2016

The constant beating of the heart requires an enormous output of energy. To meet this demand, cardiomyocytes are loaded with mitochondria, organelles that generate the majority of energy for cells. These mitochondria are dynamically regulated to ensure that damaged mitochondria are removed and replaced by healthy mitochondria.

In this month's issue of JCI Insight, James George, Anupam Agarwal, and colleagues at the University of Alabama at Birmingham examined the role of the inducible stress response gene heme oxygenase-1 in mediating mitochondrial quality control in the heart.

The research team found that overexpression of human heme oxygenase-1 in mice protected animals from dilated cardiomyopathy induced by the mitochondrial toxin doxorubicin.

Additionally, heme oxygenase-1 overexpression reduced and promoted the generation of new . Cumulatively, this study demonstrates the importance of heme oxygenase-1 in controlling in the heart.

Explore further: Host protein levels correlate with HIV-associated neurocognitive disorder

More information: Travis D. Hull et al. Heme oxygenase-1 regulates mitochondrial quality control in the heart, JCI Insight (2016). DOI: 10.1172/jci.insight.85817

Related Stories

How the cell's power station survives attacks

January 14, 2016

Mitochondria, the power generators in our cells, are essential for life. When they are under attack—from poisons, environmental stress or genetic mutations—cells wrench these power stations apart, strip out the damaged ...

Recommended for you

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.