High-dose sugammadex speeds reversal of neuromuscular block

High-dose sugammadex speeds reversal of neuromuscular block

(HealthDay)—Sugammadex at a dose of 4 mg/kg−1 of ideal body weight allows for shorter reversal of deep neuromuscular blockade in morbidly obese patients, according to a study published in the March issue of Anaesthesia.

Thibault Loupec, M.D., from the University of Poitiers in France, and colleagues conducted a single-center randomized trial in 50 morbidly . Neuromuscular blockade was monitored using acceleromyography at the adductor pollicis. Patients were randomized to sugammadex 4 mg/kg−1 (high-dose group), 2 mg/kg−1 (middle-dose group), and 1 mg/kg−1 (low-dose group) of ideal at the end of surgery with deep rocuronium-induced neuromuscular blockade.

The researchers found that the mean recovery time from deep neuromuscular blockade was significantly shorter in the high-dose group versus the middle- or low-dose group after administration of the first dose of sugammadex (255 versus 429 and 581 seconds, respectively; P < 0.001). For the high-, middle-, and low-dose groups, success rates were 93, 77, and 22 percent, respectively, from neuromuscular blockade reversal defined by a train-of-four ≥0.9 within 10 minutes after sugammadex administration (P < 0.05 compared with the lose-dose group).

"In patients, 4 mg/kg−1 of weight of sugammadex allows suitable reversal of deep rocuronium-induced neuromuscular blockade," the authors write. "Monitoring remains essential to detect residual curarisation or recurarisation."

One author disclosed financial ties to Merck Sharp & Dohme.


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Citation: High-dose sugammadex speeds reversal of neuromuscular block (2016, February 19) retrieved 20 July 2019 from https://medicalxpress.com/news/2016-02-high-dose-sugammadex-reversal-neuromuscular-block.html
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