A pharmacological approach to improving pancreatic beta cell growth and function

β cells in pancreatic islets are responsible for producing insulin, which is essential to regulate blood glucose homeostasis. In type 1 diabetes, pancreatic β cells are destroyed due to an autoimmune attack, whereas in type 2 diabetes, pancreatic β cells may have deficiencies in secreting insulin or insulin-responding tissues can become insulin resistant.

In this month's issue of JCI Insight, Morris White and colleagues at Harvard Medical School developed a screen for that induce pancreatic β cell growth and improve function. Based on preclinical findings indicating that mice with elevated expression of the insulin receptor substrate 2 (Irs2) gene are more resistant to developing diabetes, the research team tested over 3,000 compounds for their ability to increase IRS2 in isolated human .

The positive hits included 15 tricyclic compounds, several of which have been previously characterized to act as antihistamines or antipsychotics. Further studies focused on trimeprazine, an antihistamine and sedative that has been used clinically outside of the U.S. In multiple mouse models of diabetes and in human islets, trimeprazine improved β cell function and slowed progression of diabetes.

These studies suggest that trimeprazine and related compounds merit further study as therapeutics.

Explore further

Insulin-secreting cells report on insulin resistance

More information: Alexandra Kuznetsova et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice, JCI Insight (2016). DOI: 10.1172/jci.insight.80749
Citation: A pharmacological approach to improving pancreatic beta cell growth and function (2016, March 17) retrieved 2 July 2022 from https://medicalxpress.com/news/2016-03-pharmacological-approach-pancreatic-beta-cell.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors