Spider toxin analogue may help relieve pain
New research suggests that a compound based on a spider toxin may be effective for treating pain.
Experiments conducted in rats revealed that the compound, called PnPP-19, provided pain relief most likely by acting on receptors in the nervous system that also bind opioids and cannabis (or marijuana). Interestingly, PnPP-19 is also being studied as a drug candidate to treat erectile dysfunction.
"Our findings reveal at least part of the mechanism of action underlying the pain relieving effects induced by PnPP-19," said Dr. Maria de Lima, lead author of the British Journal of Pharmacology study. "They also may contribute to the consideration of PnPP-19 as a potential lead compound for the development of new drug candidates to treat pain."
More information: A C N Freitas et al. PnPP-19, a spider toxin analogue, induces peripheral antinociception through opioid and cannabinoid receptors and inhibition of Neutral endopeptidase, British Journal of Pharmacology (2016). DOI: 10.1111/bph.13448
