Is there association between MC1R and melanoma risk after controlling for sun?

There is a well-described association between UV radiation exposure from the sun and the development of melanoma. The development of melanoma independent of sun exposure has only recently been described in mice.

So what is the association between melanocortin-1 (MC1R) receptor and melanoma risk in humans after controlling for ?

An article published online by JAMA Dermatology by Judith Wendt, M.D., Ph.D., of the Medical University of Vienna, Austria, and coauthors details a hospital-based study they conducted that included genetic testing, questionnaires and other data among 991 patients with melanoma and 800 control patients for comparison.

The study findings suggest carriers of MC1R variants were at higher risk of melanoma independent of their sun exposure.

"Further studies are required to better elucidate the underlying development under altered MC1R function," the study concludes.


Explore further

Skin cancer patients not avoiding sun, study suggests

More information: JAMA Dermatology. Published online March 2, 2016. DOI: 10.1001/jamadermatol.2016.0050
Journal information: JAMA Dermatology

Citation: Is there association between MC1R and melanoma risk after controlling for sun? (2016, April 6) retrieved 16 June 2019 from https://medicalxpress.com/news/2016-04-association-mc1r-melanoma-sun.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more