High prevalence of Vitamin D deficiency in large population of kids with type 1 diabetes

April 20, 2016, University of Pennsylvania School of Nursing

During the past two decades, vitamin D status, defined as serum concentration of 25-hydroxyvitamin D, has emerged as a predictor of key clinical outcomes including bone health, glucose metabolism, cardiovascular health, immune health and survival. Now, a University of Pennsylvania School of Nursing (Penn Nursing) team, including senior author Terri Lipman, PhD, CRNP, FAAN, the Miriam Stirl Endowed Term Professor of Nutrition, Professor of Nursing of Children and Assistant Dean for Community Engagement, has examined the association between 25-hydroxyvitamin D and diabetes control in children and adolescents with type 1 diabetes.

The results demonstrate the high prevalence of patients with low levels of 25-hydroxyvitamin D, specifically in healthy weight and Caucasian children and adolescents with type 1 diabetes— patients previously considered at no or low risk of having low levels of vitamin D. These data underscore the importance of vitamin D screening in all children and adolescents with type 1 diabetes. The team's findings have been published in Diabetes Research and Clinical Practice.

"To our knowledge this is the first study that has been adequately-powered to examine the association between 25-hydroxyvitamin D and HbA1c (a measure of ) in children and adolescents with type 1 diabetes," said Lipman and colleagues. "These data suggest the need for monitoring of vitamin D in all youth with this disorder."

The study included about 200 children and adolescents from the Diabetes Center for Children at the Children's Hospital of Philadelphia, who were recruited during regular follow up visits. Non-fasting blood samples were collected from the participants to measure 25-hydroxyvitamin D and . HbA1c and other key variables were abstracted from patients' medical records.

Explore further: Vitamin D deficiency during pregnancy may increase risk of MS in children

Related Stories

Vitamin D deficiency during pregnancy may increase risk of MS in children

March 7, 2016
Children of mothers with vitamin D deficiency during early pregnancy appeared to be at greater risk for multiple sclerosis (MS) in adulthood, according to an article published online by JAMA Neurology.

Milk, vitamin supplements and exercise raise children's vitamin D levels

February 5, 2016
Sufficient intake of fortified dairy products is of significant importance for the serum vitamin D level in primary school children, shows a new study from the University of Eastern Finland. Children who drink at least three ...

Vitamin D not tied to subclinical atherosclerosis in T1DM

April 12, 2013
(HealthDay)—For individuals with type 1 diabetes, low concentrations of vitamin D metabolites are not associated with an increased risk of subclinical atherosclerosis, according to a study published online March 25 in Diabetes ...

Type 1 diabetes: Vitamin D deficiency occurs in an early stage

February 27, 2014
Vitamin D is known as a major regulator of calcium levels and bone metabolism. Furthermore, it also influences the immune system. Previous studies have shown that patients with recently diagnosed type 1 diabetes have significantly ...

Low serum 25(OH)D3 in patients newly diagnosed with T2DM

June 15, 2015
(HealthDay)—Serum 25-hydroxyvitamin D3 (25[OH]D3) is associated with glucose-stimulated insulin secretion and β-cell function in individuals with newly diagnosed type 2 diabetes, according to a study published online June ...

Recommended for you

Very low calorie diets trialled by NHS to tackle diabetes

December 7, 2018
Hundreds of thousands of people will receive NHS help to battle obesity and type 2 diabetes under radical action set out by Simon Stevens, Chief Executive of NHS England.

New therapeutic avenue for type 2 diabetes

December 6, 2018
Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers from Inserm led by Dominique Langin at the Institute of Cardiovascular and Metabolic Diseases (Inserm/Université de Toulouse) are ...

Subtype of immune B cells can delay type 1 diabetes onset in mice

December 6, 2018
A team of researchers at Baylor College of Medicine and the University of Michigan Medical School reports today in the JCI Insight that a subset of immune B cells, known as CD19+IgM+ B cells, can delay the onset of type 1 ...

Is the pancreas regeneration debate settled? An original theory renewed

December 5, 2018
A contentious debate among diabetes researchers has surrounded the regeneration of pancreatic insulin-producing cells: not if these cells regenerate, but rather how.

One in four patients say they've skimped on insulin because of high cost

December 3, 2018
For patients with diabetes, insulin is a life-saving medicine and an essential component of diabetes management, yet in the past decade alone, the out-of-pocket costs for insulin have doubled in the United States. One-quarter ...

Parsing diabetic skin infections

December 3, 2018
People with diabetes are more susceptible to skin infection. According to a new study by C. Henrique Serezani, Ph.D., Stephanie Brandt, Ph.D., and colleagues, this susceptibility might be due to overabundance of a compound ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.