Low serum 25(OH)D3 in patients newly diagnosed with T2DM
Yan Yang, from the Sichuan Provincial People's Hospital in Chengdu, China, and colleagues recruited 97 newly diagnosed type 2 diabetes patients and 69 healthy controls to assess 25(OH)D3. The authors determined 25(OH)D3 using high pressure liquid chromatography. The correlations of 25(OH)D3 with insulin resistance and β-cell function were assessed.
The researchers found that patients with newly diagnosed type 2 diabetes had much lower serum 25(OH)D3 (P < 0.01); the prevalence of hypovitaminosis 25(OH)D3 in patients with diabetes was 62.9 percent. Among patients with diabetes, those with hypovitaminosis 25(OH)D3 had higher hemoglobin A1c (HbA1c) and area under the curve for glucose (P < 0.01) and lower homeostasis model of assessment (HOMA)-β, early-phase insulin secretion index, and area under the insulin curve. There was an independent positive correlation for serum 25(OH)D3 with early-phase insulin secretion index and area under the insulin curve (P < 0.05), but not with HOMA-insulin resistance or HOMA-β. In both groups, triglycerides, HbA1c, and early-phase insulin secretion index were independent factors associated with serum 25(OH)D3.
"Serum 25(OH)D3 is not correlated with basal insulin resistance or β-cell function but is significantly positively correlated with glucose-stimulated insulin secretion and β-cell function," the authors write.
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