Resolvin D1 ameliorates inflammatory arthritis in mouse model

Rheumatoid arthritis (RA) is a debilitating autoimmune disorder that is characterized by the accumulation of inflammatory cells within the fluid of the joints. Current therapeutic strategies mostly serve to ease pain and rarely are able to reverse damage or resolve inflammation.

A study in this issue of JCI Insight indicates that the lipid mediator resolvin D1 has anti-arthritic properties and should be further explored for treating RA.

A team led by Charles Serhan of Harvard Medical School and Mauro Perritti of Queen Mary University of London determined that resolvin D1 is elevated in joint fluid from both arthritic mice and patients.

Administration of resolvin D1 in mice with dramatically reduced disease and promoted remission. The authors determined that resolvin D1 promotes expression of genes associated with cartilage repair and reduces factors associated with joint damage.

The results of this study indicate that resolving D1 be further explored as a therapeutic strategy for treating RA.

Explore further

Resolvin D1 reduces post-heart-attack heart failure

More information: Lucy V. Norling et al, Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis, JCI Insight (2016). DOI: 10.1172/jci.insight.85922
Citation: Resolvin D1 ameliorates inflammatory arthritis in mouse model (2016, April 21) retrieved 24 September 2020 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments