Candesartan doesn't prevent trastuzumab cardiotoxicity

Candesartan doesn't prevent trastuzumab cardiotoxicity
(HealthDay)—In patients with early breast cancer, candesartan does not protect against trastuzumab-related cardiotoxic effects, according to a study published online June 23 in JAMA Oncology.

Annelies H. Boekhout, Ph.D., from the Netherlands Cancer Institute in Amsterdam, and colleagues conducted a randomized -controlled trial involving 210 women with early testing positive for human epidermal growth factor receptor 2. Patients were randomized to 78 weeks of candesartan (32 mg/day) or placebo (103 in each group); treatment started on the same day as the first trastuzumab treatment.

The researchers found that 36 manifested at least one of the two primary cardiac end points. Compared with the placebo group, there were 3.8 percent more cardiac events in the candesartan group (P = 0.58), with 19 and 16 percent in each group, respectively. The two-year cumulative incidence of in the candesartan and placebo groups was 0.28 and 0.16, respectively (P = 0.56). Candesartan had no effect on changes in the N-terminal of the prohormone brain natriuretic peptide and high-sensitivity troponin T values; there was no correlation for these biomarkers with significant changes in left ventricular ejection fraction.

"The findings do not support the hypothesis that concomitant use of protects against a decrease in left ventricular ejection fraction during or shortly after trastuzumab treatment in early breast cancer," the authors write.

The study was supported by unrestricted financial contributions from Roche; AstraZeneca provided the study drug and placebo.


Explore further

SABCS: no benefit in extending trastuzumab in HER2 breast CA

More information: Abstract
Full Text
Editorial
Journal information: JAMA Oncology

Copyright © 2016 HealthDay. All rights reserved.

Citation: Candesartan doesn't prevent trastuzumab cardiotoxicity (2016, June 25) retrieved 18 June 2019 from https://medicalxpress.com/news/2016-06-candesartan-doesnt-trastuzumab-cardiotoxicity.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
1 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more