Review: similar / improved outcomes for TAVI versus SAVR

Review: similar/Improved outcomes for TAVI versus SAVR

(HealthDay)—Transcatheter aortic valve implantation (TAVI) may be associated with improved clinical outcomes versus surgical aortic valve replacement (SAVR) in adults with severe aortic stenosis, according to a review and meta-analysis published online June 7 in the Annals of Internal Medicine.

Giuseppe Gargiulo, M.D., from the Federico II University in Naples, Italy, and colleagues compared in adults with undergoing TAVI or SAVR. Data were included from five randomized trials and 31 observational matched studies involving 16,638 patients.

The researchers found that TAVI and SAVR did not differ significantly in terms of early (odds ratio, 1.01; 95 percent confidence interval, 0.81 to 1.26) or midterm (odds ratio, 0.96; 95 percent confidence interval, 0.81 to 1.14) all-cause mortality. In trials, transfemoral TAVI provided mortality benefits over SAVR. In analyses restricted to studies of patients at low to intermediate risk there were non-significant reductions in early and midterm mortality with TAVI. TAVI was associated with lower incidence of periprocedural myocardial infarction, major bleeding, acute kidney injury, and new-onset atrial fibrillation; however, TAVI was associated with increased risk for pacemaker implantation, vascular complications, and paravalvular leak. A non-significantly increased risk of long-term all-cause mortality was seen for TAVI; long-term outcomes were inconclusive for patients at low to intermediate risk.

"Compared with SAVR, TAVI may have similar or better early and midterm outcomes for with aortic stenosis, including those at low to intermediate risk," the authors write.

One author disclosed financial ties to Edwards Lifesciences.

More information: Full Text (subscription or payment may be required)

Journal information: Annals of Internal Medicine

Copyright © 2016 HealthDay. All rights reserved.

Citation: Review: similar / improved outcomes for TAVI versus SAVR (2016, June 7) retrieved 30 November 2023 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Delirium predicts function in elderly after aortic valve surgery


Feedback to editors