Mitochondria-targeted iron chelator offers photoprotection

Mitochondria-targeted iron chelator offers photoprotection

(HealthDay)—A mitochondria-targeted iron chelator can protect primary skin fibroblasts against the harmful effects of ultraviolet A (UVA), according to a study published in the August issue of the Journal of Investigative Dermatology.

Olivier Reelfs, Ph.D., from the University of Bath in the United Kingdom, and colleagues designed a mitochondria-targeted hexadentate iron chelator linked to mitochondria-homing SS-like peptides. They evaluated the photoprotective potential of this compound against UVA-induced oxidative damage and cell death in cultured primary skin fibroblasts.

The researchers found that the compound provided protection against UVA-induced mitochondrial damage, depletion of , and the ensuing necrotic cell death. This effect was fully related to the iron-chelating property in the mitochondria.

"This mitochondria-targeted iron chelator has therefore promising potential for skin photoprotection against the deleterious effects of the UVA component of sunlight," the authors write.


Explore further

Sun cream compound offers unprecedented protection against UVA radiation

More information: Abstract
Full Text

Copyright © 2016 HealthDay. All rights reserved.

Citation: Mitochondria-targeted iron chelator offers photoprotection (2016, July 29) retrieved 8 April 2020 from https://medicalxpress.com/news/2016-07-mitochondria-targeted-iron-chelator-photoprotection.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
4 shares

Feedback to editors

User comments