Advanced glycation end products tied to renal function loss

Advanced glycation end products tied to renal function loss

(HealthDay)—For American-Indians with type 2 diabetes, advanced glycation end products (AGEs) are associated with renal function loss (RFL), according to a study published online Sept. 8 in Diabetes.

Pierre-Jean Saulnier, M.D., Ph.D., from the Phoenix Epidemiology and Clinical Research Branch, and colleagues used data from a six-year clinical trial to examine of AGEs with RFL and its structural determinants in American-Indians with type 2 diabetes.

The researchers found that during a median follow-up of 8.0 years, 104 of 168 participants reached the RFL end point (≥40 percent decline of measured from baseline). Each doubling of carboxyethyl lysine or methylglyoxal hydroimidazolone concentration correlated with RFL after multivariable adjustment (hazard ratios, 1.60 and 1.30, respectively). There were positive correlations for carboxyethyl lysine, carboxymethyl lysine, and methylglyoxal hydroimidazolone with cortical interstitial fractional volume (P = 0.03, 0.02, and 0.003, respectively). Negative correlations were seen for glyoxyl hydroimidazolone and methylglyoxal hydroimidazolone with total filtration surface per glomerulus (P = 0.01 and 0.046, respectively).

"AGEs improve prediction of RFL and its major structural correlates," the authors write.

Two authors disclosed financial ties to PreventAGE Healthcare, where the assays of AGE were performed.

More information: Full Text (subscription or payment may be required)

Journal information: Diabetes

Copyright © 2016 HealthDay. All rights reserved.

Citation: Advanced glycation end products tied to renal function loss (2016, September 13) retrieved 25 June 2024 from https://medicalxpress.com/news/2016-09-advanced-glycation-products-tied-renal.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Liraglutide, sitagliptin have no effect on renal hemodynamics

2 shares

Feedback to editors