More diabetes-associated, non-associated autoantibodies in T1D

September 6, 2016

(HealthDay)—Patients with type 1 diabetes have more diabetes-associated autoantibodies (DAAs) and non-DAAs than patients with type 2 diabetes, according to a study published online Aug. 29 in Diabetes Care.

Nanette C. Schloot, M.D., from Heinrich-Heine University in Düsseldorf, Germany, and colleagues analyzed patients with adult-onset type 1 (80 patients: 50 with latent autoimmune diabetes in adults [LADA] and 30 with classic type 1 diabetes) and type 2 diabetes (626 patients) for DAAs (GAD antibody [GADA], IA-2 antigen, islet cell antibody, and zinc transporter T8), non-DAAs (transglutaminase, thyroid peroxide autoantibodies, parietal cell antibodies), and concentrations of 10 immune mediators.

The researchers found that patients with type 1 diabetes (LADA or classic) could not be differentiated by autoantibodies or immune mediators. Nine of 10 immune mediators were negatively correlated with DAA titers in type 1 diabetes. Type 2 patients had no DAAs and had fewer non-DAAs (P < 0.0005), but had higher levels of proinflammatory immune mediators, especially compared to with type 1 diabetes who had high GADA titers.

"Differences in the clinical classification of diabetes are associated with graded differences in adaptive and innate immune reactivity," the authors write.

Two authors disclosed financial ties to the pharmaceutical industry; the study was partially funded by DeveloGen.

Explore further: Risk of T1DM up in children with autoantibody reversion

More information: Full Text (subscription or payment may be required)

Related Stories

Risk of T1DM up in children with autoantibody reversion

June 21, 2016
(HealthDay)—The risk of type 1 diabetes remains elevated for children who have developed multiple β-cell autoantibodies, even after reversion of individual autoantibodies, according to a study published online June 16 ...

Increasing shift from islet antibody positivity to diabetes

March 2, 2012
(HealthDay) -- There is an increase in both the prevalence and levels of islet antigen-2 and zinc transporter 8, as well as in autoantibodies, in newly diagnosed type 1 diabetes patients during a period of rising disease ...

Delta9-tetrahydrocannabivarin beneficial in type 2 diabetes

September 1, 2016
(HealthDay)—For patients with non-insulin-treated type 2 diabetes, Δ9-tetrahydrocannabivarin (THCV) reduces fasting plasma glucose, and improves pancreatic β-cell function, adiponectin, and apolipoprotein A, according ...

Antibody affinity is decisive in Type 1 diabetes in adults

March 11, 2014
Patients with LADA – a form of autoimmune type 1 diabetes in adulthood – can be distinguished from patients with non-autoimmune type 2 diabetes by means of the antibody reaction affinity to the enzyme glutamic acid decarboxylase ...

Antibodies in patients with rare disorder may have role preventing type 1 diabetes

July 14, 2016
People with a rare autoimmune disorder produce autoimmune antibodies that appear to be linked to a reduced occurrence of Type 1 diabetes, new research has found. The study, published in Cell, suggests these antibodies could ...

Metformin linked to increased risk of acute dialysis in T2DM

August 23, 2016
(HealthDay)—For patients with type 2 diabetes, metformin is associated with about a 50 percent increase in the risk of acute dialysis compared to sulfonylureas, according to a study published online Aug. 18 in Diabetes, ...

Recommended for you

Physical exercise reduces risk of developing diabetes: study

February 20, 2018
Exercising more reduces the risk of diabetes and could see seven million fewer diabetic patients across mainland China, Hong Kong and Taiwan, according to new research.

Researchers find existing drug effective at preventing onset of type 1 diabetes

February 15, 2018
A drug commonly used to control high blood pressure may also help prevent the onset of type 1 diabetes in up to 60 percent of those at risk for the disease, according to researchers at the University of Colorado Anschutz ...

Chemist designs diabetic treatment minus harmful side effects

February 9, 2018
A chemist in the College of Arts and Sciences (A&S) has figured out how to control glucose levels in the bloodstream without the usual side effects of nausea, vomiting or malaise.

Peptide improves glucose and insulin sensitivity, lowers weight in mice

February 8, 2018
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School ...

Study reports use of nutritional ketosis with mobile app intervention could reverse Type 2 diabetes

February 7, 2018
A newly published study has shown that an individualized approach to nutritional ketosis (utilizing fat rather than glucose to fuel the body), combined with remote monitoring via a mobile application, could sustainably and ...

Simple molecule could prevent, alleviate pre-diabetes

February 7, 2018
Restoring levels of coenzyme Q10 (CoQ), a key molecule in energy production in cells, could overcome insulin resistance or pre-diabetes—a precursor to type 2 diabetes and cardiovascular disease.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.