Research points to new treatment strategy against Alzheimer's disease

New research suggests that Alzheimer's disease may trigger increased expression of an enzyme called lysozyme, which attempts to counteract amyloid build-up in the brain.

Investigators found that the expression of was increased in the brains of both and humans with Alzheimer's disease. Furthermore, lysozyme had favorable effects when expressed in different fly models of Alzheimer's disease.

The findings indicate that lysozyme may represent an important clinical marker of Alzheimer's disease and also point to new therapeutic strategy that may help slow the disease's progression.

"These findings are exceptionally interesting since lysozyme also rescued transgenic Alzheimer flies with the 'Arctic' mutation, a familial aggressive form of Alzheimer's disease," said Dr. Katarina Kagedal, senior author of The FEBS Journal study.

Explore further

'Pac-Man' gene implicated in Alzheimer's disease

More information: Linnea Sandin et al. Beneficial effects of increased lysozyme levels in Alzheimer's disease modelled in, The FEBS Journal (2016). DOI: 10.1111/febs.13830
Provided by Wiley
Citation: Research points to new treatment strategy against Alzheimer's disease (2016, September 7) retrieved 24 January 2022 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors