Intestinal diversity protects against asthma

Intestinal diversity protects against asthma
Researchers at Linköping University, Sweden, study whether intestinal bacteria play a role in the development of allergy and asthma. Credit: Thor Balkhed, Linköping University

Children who develop asthma or allergies have an altered immune response to intestinal bacteria in the mucous membranes even when infants, according to a new study from Linköping University, Sweden, and Center for Advanced Research in Public Health, Spain. The results also suggests that the mother's immune defence plays a role in the development of asthma and allergies in children.

"The results confirm our idea that the (also known as the 'intestinal microbiota') early in life plays a role during the development of . We believe that diversity among the bacteria contributes to strengthening the immune defence in the mucous membranes. In our new study we saw differences in the immune response against intestinal bacteria in who subsequently developed allergy symptoms," says Maria Jenmalm, professor of experimental allergology at Linköping University and one of the authors of the study.

The researchers investigated in detail the immune defence of the mucous membranes against different bacteria. Mucous membranes are present in the airways and gastrointestinal tract, where they come into contact with large amounts of bacteria and viruses. High concentrations of antibodies known as "IgA antibodies" are present in mucous membranes. They bind to microorganisms that they recognise and act as a barrier, preventing them from entering the body.

The researchers in the new study analysed stool samples from infants aged one month and again at 12 months. The first year of life has a profound influence on how the reacts later in life when challenged with bacteria, viruses and allergens. The researchers identified the intestinal bacteria and determined whether they had IgA bound to them or not.

"Children who subsequently developed allergies had a lower fraction of IgA antibodies bound to their intestinal bacteria when aged 12 months than children who did not. This difference may suggest that the barrier function of the is less effective in children who later develop allergies. The lack of IgA was particularly noticeable in children who developed asthma during the first seven years of life," says Maria Jenmalm.

The researchers looked at the composition of the bacteria in the stools and used bioinformatic methods to study differences in IgA antibodies against between healthy and allergic children.

"There were clear differences in the types of bacteria that the immune defences of the two groups of children reacted against. We were interested to note that these differences were clear in infants as young as one month. This surprised us, since the IgA antibodies in children so young come largely from the mother, through breast milk. So it seems that the of the mother and the antibodies that the child receives in are connected with the development of allergies. This is something we want to look at in more detail," says Maria Jenmalm.

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More information: Majda Dzidic et al. Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development, Journal of Allergy and Clinical Immunology (2016). DOI: 10.1016/j.jaci.2016.06.047
Citation: Intestinal diversity protects against asthma (2016, October 10) retrieved 20 January 2021 from
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