Keeping your synapses sharp: How spermidine reverses age-related memory decline

Keeping your synapses sharp: How spermidine reverses age-related memory decline
Electron micrographs revealed the alignment of the plasma membrane, with evident increase in extracellular spacing between cellular elements, to be affected in 30d w1118 flies, when compared to 3d or 30dSpd w1118 flies. Credit: Gupta VK, Pech U, Bhukel A, Fulterer A, Ender A, Mauermann SF, et al.

Synapses, connecting the neurons in our brains, continuously encode new memories, but the ability to form new memories ("learning") diminishes drastically for many of us as we get older.

In the article published September 29 in open-access journal PLOS Biology, work by the groups of Stephan Sigrist from the Freie Universität Berlin, Andrea Fiala (Universität Göttingen) and Frank Madeo (Universität Graz) now shows that specific changes at the level of synapses directly provoke age-related dementia, and that, however, administering a simple substance already found in our bodies, spermidine, can help to avoid such age-related synaptic changes and thereby protect from age-induced memory impairment.

Just like humans, the fruit fly Drosophila melanogaster - a leading model for aging research - suffers from memory impairment with advancing age. The same team of researchers previously observed that Drosophila exhibits an age-induced decline in levels of spermidine, and that these memory deficits can be suppressed by feeding with a diet supplemented by spermidine. They now describe an unexpected scenario that convincingly explains the suppression of by spermidine feeding. In a nutshell, synapses within the Drosophila brain seem to narrow their operational space, and thus become increasingly unable to form with age.

Dietary supplementation with spermidine, however, prevented these changes. Importantly, when the authors mimicked these age-associated changes by genetic means, learning suffered even in young flies, providing a causal link between generic synaptic mechanisms and age-induced memory impairment. This work promises to open up a new avenue when searching for new therapeutic strategies to fight age-associated dementia, a major health threat of our times.

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Feeding fruit flies with spermidin suppresses age-dependent memory impairment

More information: Varun K. Gupta et al, Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release, PLOS Biology (2016). DOI: 10.1371/journal.pbio.1002563
Journal information: PLoS Biology

Citation: Keeping your synapses sharp: How spermidine reverses age-related memory decline (2016, October 3) retrieved 19 October 2019 from
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