Cumulative incidence of ESRD low in patients with type 1 DM

November 8, 2016

(HealthDay)—Patients with type 1 diabetes diagnosed at age 15 to 27 years have low cumulative incidence of end-stage renal disease (ESRD) and increased mortality during long-term follow-up, according to a study published online Oct. 21 in Diabetes Care.

Vibeke Gagnum, from Oslo University Hospital in Norway, and colleagues examined the long-term mortality, causes of death, and ESRD in a population-based cohort study involving 719 patients with type 1 diabetes diagnosed at ages 15 to 27 years. Information on causes of death and whether ESRD was present was obtained from linkage to national registries.

The researchers found that 4.6 percent of participants developed ESRD and 20.6 percent died during 30 years of follow-up. Cumulative mortality was 6.0 percent at 10 years since diagnosis, 12.2 percent at 20 years, and 18.4 percent at 30 years. The standardized mortality ratio was 4.4. There was a mean of 23.6 years from diabetes diagnosis to ESRD. Causes of death included (32.2 percent), acute complications (20.5 percent), violent death (19.9 percent), or any other cause (27.4 percent). In 15 percent of cases, death was related to alcohol.

"The cumulative incidence of ESRD was low in this cohort with type 1 followed for 30 years," the authors write. "Mortality was 4.4 times that of the general population, and more than 50 percent of all deaths were caused by acute or chronic complications."

Explore further: Decline in eGFR mainly linear in type 1 diabetes

More information: Full Text (subscription or payment may be required)

Related Stories

Decline in eGFR mainly linear in type 1 diabetes

September 22, 2016
(HealthDay)—For patients with type 1 diabetes, the decline of estimated glomerular filtration rate (eGFR) is mainly linear, according to a study published online Sept. 19 in Diabetes Care.

Diabetes linked to increased CVD, cancer, other mortality

August 19, 2016
(HealthDay)—Diabetes is associated with increased mortality from cardiovascular disease, cancer, and noncardiovascular noncancer causes, according to a study published online Aug. 4 in Diabetes Care.

Systolic blood pressure variability linked to mortality, morbidity

September 29, 2016
(HealthDay)—Systolic blood pressure variability (SBPV) is associated with mortality, coronary heart disease (CHD), stroke, and end-stage renal disease (ESRD), according to a study published in the Sept. 27 issue of the ...

ASN: Bardoxolone methyl no benefit in T2DM, stage 4 CKD

November 11, 2013
(HealthDay)—Bardoxolone methyl does not reduce the risk of end-stage renal disease (ESRD) or cardiovascular death in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease, according to a study published ...

Chronic kidney disease a warning sign independent of hypertension or diabetes

September 25, 2012
Two new studies from the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium found that the presence of chronic kidney disease itself can be a strong indicator of the risk of ...

Recommended for you

Researchers discover link between gut and type 1 diabetes

February 19, 2018
Scientists have found that targeting micro-organisms in the gut, known as microbiota, could have the potential to help prevent type 1 diabetes.

Researchers find existing drug effective at preventing onset of type 1 diabetes

February 15, 2018
A drug commonly used to control high blood pressure may also help prevent the onset of type 1 diabetes in up to 60 percent of those at risk for the disease, according to researchers at the University of Colorado Anschutz ...

Chemist designs diabetic treatment minus harmful side effects

February 9, 2018
A chemist in the College of Arts and Sciences (A&S) has figured out how to control glucose levels in the bloodstream without the usual side effects of nausea, vomiting or malaise.

Peptide improves glucose and insulin sensitivity, lowers weight in mice

February 8, 2018
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School ...

Study reports use of nutritional ketosis with mobile app intervention could reverse Type 2 diabetes

February 7, 2018
A newly published study has shown that an individualized approach to nutritional ketosis (utilizing fat rather than glucose to fuel the body), combined with remote monitoring via a mobile application, could sustainably and ...

Simple molecule could prevent, alleviate pre-diabetes

February 7, 2018
Restoring levels of coenzyme Q10 (CoQ), a key molecule in energy production in cells, could overcome insulin resistance or pre-diabetes—a precursor to type 2 diabetes and cardiovascular disease.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.