Impact of HbA1c, BMI changes on lipids varies as children age

Impact of HbA1c, BMI changes on lipids varies as children age

(HealthDay)—As children age, the impact of changes in hemoglobin A1c (HbA1c) and body mass index (BMI) on low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol levels increases, according to a study published online Oct. 20 in Diabetes Care.

Michelle L. Katz, M.D., M.P.H., from the Joslin Diabetes Center in Boston, and colleagues conducted a dynamic, retrospective study examining changes in lipid values in 572 young people with type 1 diabetes followed longitudinally for a median of 9.3 years. After adjustment for other relevant factors, the relationship between HbA1c and BMI z score (zBMI) on lipid values was described as subjects aged.

The researchers found that each 1 percent increase in HbA1c correlated with a 2 to 6 mg/dL increase in LDL levels; as subjects progressed from pre- to post-pubertal age ranges the increase was greater. When subjects were 10 years old, a one standard deviation increase in BMI correlated with a mean LDL increase of 2.1 mg/dL, compared with a mean increase of 8.2 mg/dL when subjects were 19 years old. Similar correlations were seen for HbA1c level and zBMI changes and variation in non-HDL levels. A small influence was seen for HBA1c and zBMI on HDL levels, which was not dependent on age.

"Changes in HbA1c level and zBMI modestly impact LDL and non-HDL cholesterol and have greater impacts as children age," the authors write.

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Citation: Impact of HbA1c, BMI changes on lipids varies as children age (2016, November 2) retrieved 29 June 2022 from
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